ANTIOXIDANT EFFECTS OF CARVEDILOL IN HYPERTENSIVE, CHRONIC SMOKERS

卡维地洛对高血压、长期吸烟者的抗氧化作用

• 批准号: 6244490
• 负责人: GARRET A FITZGERALD
• 金额: $ 2.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-17 至 1998-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244490
• 关键词: antihypertensive agents; antioxidants; ascorbate; cardiovascular disorder chemotherapy; chlorothiazide; clinical research; clinical trials; drug screening /evaluation; human subject; human therapy evaluation; hypertension; outcomes research; tobacco abuse; tocopherols

This study is being conducted in patients to determine if carvedilol has properties similar to those of an antioxidant. Antioxidants consist of drugs and vitamins that prevent or correct certain chemical reactions from occuring in the body. Such reactions may be harmful so that their prevention by an antioxidant may be beneficial. The objectives of this study is to explore the antioxidant effects of carvedilol following single and repeat oral dosing at two dose levels as compared to dosing with an antioxidant control (Vitamins C and E) and a hypotensive control (hydrochlorothiazide) in hypertensive, chronic smokers.

这项研究是在患者中进行的，以确定卡维地洛是否有