Institutional Clinical and Translational Science Award

机构临床和转化科学奖

• 批准号: 10646280
• 负责人: GARRET A FITZGERALD
• 金额: $ 1024.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646280
• 关键词: Adult; Biological Models; Cells; Childhood; Clinical Sciences; Clinical and Translational Science Awards; Democracy; Discipline; Disease; Education; Fostering; Funding; Growth; Home; Human; Institution; Persons; Phenotype; Physiology; Research; Research Personnel; Resources; Science; Translational Research; clinical implementation; drug action; novel; programs; recruit; translational medicine; translational therapeutics

OVERALL ABSTRACT/SUMMARY The Institute for Translational Medicine and Therapeutics is the academic home for the CTSA in Penn. For the past decade and a half the objectives of ITMAT have been and remain (i) to increase the number of investigators capable of pursuing their research between proof of concept in cells and model systems and (ii) elucidation of the mechanisms of human physiology, disease or drug action through intense phenotyping in small numbers of people. The two priorities of our CTSA are to foster the field of translational therapeutics and to bridge the pediatric to adult divide across the entire spectrum of clinical and translational science. This section describes how these priorities have influenced the growth of this CTSA Hub and outlines our plans for the coming funding period.

全面的 摘要/总结 转化医学和治疗研究所是 CTSA 的学术所在地 佩恩。在过去的十五年里，ITMAT 的目标一直是并且仍然是 (i) 增加能够在证明之间进行研究的调查人员数量 细胞和模型系统中的概念以及（ii）阐明人类生理学机制， 通过少数人的强烈表型分析来确定疾病或药物作用。两人 我们 CTSA 的首要任务是促进转化治疗领域的发展并架起桥梁 从儿科到成人的划分跨越了整个临床和转化科学领域。这 部分描述了这些优先事项如何影响该 CTSA 中心的发展并概述 我们对未来资助期的计划。

项目成果

Occult Hepatocellular Carcinoma Associated With Transjugular Intrahepatic Portosystemic Shunts in Liver Transplant Recipients.

• DOI: 10.1002/lt.26073
• 发表时间: 2021-09
• 期刊: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
• 作者: Krumeich LN;Mancinelli J;Cucchiara A;Eddinger K;Aufhauser D Jr;Goldberg DW;Siegelman ES;Rosen M;Reddy KR;Hoteit M;Furth EE;Olthoff KM;Shaked A;Levine M;Abt P
• 通讯作者: Abt P

Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography.

• DOI: 10.1039/c6nr02618d
• 发表时间: 2016-07-14
• 期刊: Nanoscale
• 影响因子: 6.7
• 作者: Naha PC;Lau KC;Hsu JC;Hajfathalian M;Mian S;Chhour P;Uppuluri L;McDonald ES;Maidment AD;Cormode DP
• 通讯作者: Cormode DP

Phenotypic homogeneity in childhood epilepsies evolves in gene-specific patterns across 3251 patient-years of clinical data.

• DOI: 10.1038/s41431-021-00908-8
• 发表时间: 2021-11
• 期刊: European journal of human genetics : EJHG
• 作者: Lewis-Smith D;Ganesan S;Galer PD;Helbig KL;McKeown SE;O'Brien M;Khankhanian P;Kaufman MC;Gonzalez AK;Felmeister AS;Krause R;Ellis CA;Helbig I
• 通讯作者: Helbig I

Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.

• DOI: 10.1371/journal.pone.0192779
• 发表时间: 2018
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wang Q;Guo L;Strawser CJ;Hauser LA;Hwang WT;Snyder NW;Lynch DR;Mesaros C;Blair IA
• 通讯作者: Blair IA

Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study.

• DOI: 10.1186/s12889-022-12569-3
• 发表时间: 2022-01-27
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Penrod NM;Moore JH
• 通讯作者: Moore JH