Institutional Clinical and Translational Science Award

机构临床和转化科学奖

• 批准号: 10646280
• 负责人: GARRET A FITZGERALD
• 金额: $ 1024.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646280
• 关键词: Adult; Biological Models; Cells; Childhood; Clinical Sciences; Clinical and Translational Science Awards; Democracy; Discipline; Disease; Education; Fostering; Funding; Growth; Home; Human; Institution; Persons; Phenotype; Physiology; Research; Research Personnel; Resources; Science; Translational Research; clinical implementation; drug action; novel; programs; recruit; translational medicine; translational therapeutics

OVERALL ABSTRACT/SUMMARY The Institute for Translational Medicine and Therapeutics is the academic home for the CTSA in Penn. For the past decade and a half the objectives of ITMAT have been and remain (i) to increase the number of investigators capable of pursuing their research between proof of concept in cells and model systems and (ii) elucidation of the mechanisms of human physiology, disease or drug action through intense phenotyping in small numbers of people. The two priorities of our CTSA are to foster the field of translational therapeutics and to bridge the pediatric to adult divide across the entire spectrum of clinical and translational science. This section describes how these priorities have influenced the growth of this CTSA Hub and outlines our plans for the coming funding period.

全面的 摘要/摘要 转化医学与治疗学研究所是CTSA的学术意义 宾夕法尼亚在过去的十年半中 增加了能够在证明证明之间进行研究的调查人员的数量 细胞和模型系统中的概念以及（ii）阐明人类生理机制的概念， 疾病或药物作用通过少数人的强烈表型来作用。两个 我们CTSA的优先事项是促进转化治疗领域并桥接 在整个临床和转化科学范围内，小儿到成人分裂。这 部分描述了这些优先级如何影响该CTSA枢纽和轮廓的增长 我们在即将到来的资金期间的计划。

项目成果

Walking speed influences spatiotemporal but not symmetry measures of gait in children and adolescents with hemiplegia.

步行速度影响偏瘫儿童和青少年的步态时空测量，但不影响步态对称性测量。

• DOI: 10.1016/j.gaitpost.2022.09.088
• 发表时间: 2022
• 期刊: Gait & posture
• 影响因子: 2.4
• 作者: Prosser,LauraA;Atkinson,HeatherL;Alfano,JamesM;Kessler,SudhaK;Ichord,RebeccaB
• 通讯作者: Ichord,RebeccaB

Harnessing Progress in Psychiatric Genetics to Advance Population Mental Health.

利用精神病遗传学的进展来促进人口心理健康。

• DOI: 10.2105/ajph.2019.304948
• 发表时间: 2019
• 期刊: American journal of public health
• 影响因子: 12.7
• 作者: Merikangas,KathleenRies;Merikangas,AlisonK
• 通讯作者: Merikangas,AlisonK

A deep learning method to detect opioid prescription and opioid use disorder from electronic health records.

一种从电子健康记录中检测阿片类药物处方和阿片类药物使用障碍的深度学习方法。

• DOI: 10.1016/j.ijmedinf.2022.104979
• 发表时间: 2023
• 期刊: International journal of medical informatics
• 影响因子: 4.9
• 作者: Kashyap,Aditya;Callison-Burch,Chris;Boland,MaryRegina
• 通讯作者: Boland,MaryRegina

Antihypertensive effects of yoga in a general patient population: real-world evidence from electronic health records, a retrospective case-control study.

• DOI: 10.1186/s12889-022-12569-3
• 发表时间: 2022-01-27
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Penrod NM;Moore JH
• 通讯作者: Moore JH

Delineating clinical and developmental outcomes in STXBP1-related disorders.

描述 STXBP1 相关疾病的临床和发育结果。

• DOI: 10.1101/2023.05.10.23289776
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Xian,Julie;Thalwitzer,KimMarie;McKee,Jillian;Sullivan,KatieRose;Brimble,Elise;Fitch,Eryn;Toib,Jonathan;Kaufman,MichaelC;deCampo,Danielle;Cunningham,Kristin;Pierce,SamuelR;Goss,James;Rigby,CharleneSon;Syrbe,Steffen;Boland,
• 通讯作者: Boland,