OUTCOME OF PATIENTS W/CONGENITAL HEART MALFORMATIONS FOLLOWING FONTAN PROCEDURE

先天性心脏畸形患者接受 Fontan 手术后的结果

• 批准号: 6244681
• 负责人: CAREN S GOLDBERG
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244681
• 关键词: central nervous system; child (0-11); clinical research; congenital heart disorder; developmental neurobiology; heart surgery; human subject; outcomes research; physiologic stressor

OBJECTIVE: Evaluate the neurodevelopmental outcome (NDO) of patients with hypoplastic left heart synbdrome (HLHS) following surgical palliation. APPROACH: 1) Perform neurodevelopmental testing on HLHS patients; 2) Compare NDO of HLHS patients to NDO of healthy children and to NDO of patients with non-HLHS congenital heart lesions requiring a similar surgical approach; 3) Evaluate factors in these patients which may contribute to abnormal neurodevelopment including structural abnormalities of the central nervous system and perioperative stresses. SIGNIFICANCE: May impact future approach to treating patients with HLHS.

目的：评价患者的神经发育结局（NDO） 手术后患有左心发育不全综合征（HLHS） 姑息 方法：1）对HLHS患者进行神经发育测试; 2） 将HLHS患者的NDO与健康儿童的NDO以及 患有非HLHS先天性心脏病的患者，需要类似的 手术入路; 3）评估这些患者中可能 有助于异常的神经发育，包括结构 中枢神经系统异常和围手术期压力。 意义：可能影响未来治疗患者的方法 HLHS。