Pediatric Heart Network Regents of the University of Michigan

密歇根大学儿科心脏网络董事会

• 批准号: 10544165
• 负责人: CAREN S GOLDBERG
• 金额: $ 34.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544165
• 关键词: Address; Adolescence; Adult; Area; Birth; Cardiac; Cardiac Surgery procedures; Caring; Child; Childhood; Clinical; Clinical Trials; Common Ventricle; Congenital Abnormality; Congenital Cardiovascular Abnormality; Congenital Heart Defects; Critical Care; Data; Databases; Development; Devices; Ensure; Environment; Extramural Activities; Faculty; Financial Support; Fostering; Funding; Genetic; Goals; Healthcare; Heart; Heart Diseases; Hospitals; Individual; Infrastructure; Knowledge; Lead; Leadership; Lesion; Mentors; Methodology; Michigan; Morbidity - disease rate; Multicenter Studies; National Heart, Lung, and Blood Institute; Outcome; PC4 Gene; Participant; Pediatrics; Play; Population; Productivity; Registries; Research; Research Infrastructure; Research Personnel; Resources; Sample Size; Training; Universities; Variant; Work; biobank; clinical infrastructure; congenital heart disorder; data integration; data registry; data sharing; disease heterogeneity; experience; improved; innovation; large datasets; mortality; neurodevelopment; novel; novel therapeutics; randomized trial; reconstruction; success; treatment and outcome

ABSTRACT This proposal leverages strengths across the University of Michigan to support the Michigan Congenital Heart Center as a productive collaborator, leader, and innovator in advancing efforts of the Pediatric Heart Network (PHN) toward improving care and outcomes of pediatric and congenital cardiovascular disease. Michigan Congenital Heart Center investigators have played key roles in many prior and ongoing PHN studies, including leading the Single Ventricle Reconstruction Trial (the first multicenter randomized trial in the pediatric cardiac surgery), directing the biorepository for several PHN studies, and leading the PHN Integrated CARdiac Data and Outcomes (iCARD) Collaborative. Continued participation of centers with strong clinical and research infrastructure, and experience in leading multi-center collaborative research is needed to further the important work of the PHN. In addition, there are new challenges in the current era, including conducting research more efficiently, better utilizing the ever-increasing volume of healthcare data, and investigating novel therapies and devices to drive further improvements in outcomes (particularly longer-term outcomes), and tailoring these to specific clinical and genetic profiles. Our proposal has two aims – first, we aim to serve as a collaborative participant and leader in furthering the work of the PHN to address important questions in pediatric and congenital cardiovascular disease. Our track record of success, and unique and comprehensive resources, infrastructure, and expertise will ensure our ability to participate fully across PHN studies and lead efficient and collaborative research. In particular, our expertise specifically related to the study of novel therapies and devices, assessment of longer-term outcomes (including neurodevelopment), and underlying genetic factors, will allow us to lead efforts to address key questions in these areas. Our numerous faculty with independent research funding, training resources, and mentoring expertise will foster our ability to compete successfully for extramural research funding to further support PHN activities. Second, we aim to lead innovative data integration and sharing efforts to foster novel and efficient PHN research. Our investigators have extensive expertise in this area, including pioneering initial linkages across large datasets in the field (supported by NHLBI R01 funding), and creating a state of the art platform to share information across centers within the Pediatric Cardiac Critical Care Consortium (PC4). Through our leadership of the recently formed PHN iCARD Collaborative, we will work to bring innovations in this area to the PHN, including integrating existing and emerging data to allow novel studies otherwise not possible, and to support more efficient conduct of research. Participation and leadership of the Michigan Congenital Heart Center will foster continued success of the PHN, and allow the network to meet the challenges of the current healthcare and research environments to continue to advance the treatment and outcomes of pediatric and congenital cardiovascular disease.

摘要 该提案利用密歇根大学的优势来支持密歇根先天性心脏病 中心作为一个富有成效的合作者，领导者和创新者，在推进儿童心脏网络的努力 (PHN)致力于改善儿科和先天性心血管疾病的护理和预后。密歇根 先天性心脏病中心的研究人员在许多先前和正在进行的PHN研究中发挥了关键作用，包括 领导单支气管重建试验（第一个多中心随机试验，在小儿心脏 手术），指导几项PHN研究的生物储存库，并领导PHN综合心脏数据 和成果（iCARD）协作。具有强大临床和研究能力的中心继续参与 基础设施，并在领导多中心合作研究的经验，需要进一步的重要 PHN的工作。此外，当前时代还有新的挑战，包括开展更多研究 有效地，更好地利用不断增加的医疗数据量，并研究新的治疗方法， 推动进一步改善结果（特别是长期结果）的设备，并将其定制为 具体的临床和遗传特征。我们的建议有两个目标-第一，我们的目标是作为一个合作 参与者和领导者，推动PHN的工作，以解决儿科和 先天性心血管疾病我们的成功记录，独特而全面的资源， 基础设施和专业知识将确保我们有能力充分参与PHN研究， 合作研究。特别是，我们的专业知识特别涉及新疗法的研究， 器械、长期结局评估（包括神经发育）和潜在遗传因素， 将使我们能够领导解决这些领域关键问题的努力。我们拥有众多独立教师 研究资金、培训资源和指导专业知识将培养我们成功竞争的能力， 为进一步支持PHN活动提供校外研究资金。第二，我们旨在引领创新数据 整合和共享努力，以促进新的和有效的PHN研究。我们的调查员有大量 这一领域的专门知识，包括开拓外地大型数据集之间的初步联系（由 NHLBI R 01资金），并创建一个最先进的平台，在 儿科心脏重症监护联盟（PC 4）。通过我们对最近成立的PHN iCARD的领导 通过合作，我们将努力为PHN带来这一领域的创新，包括整合现有的 新出现的数据，使新的研究，否则不可能，并支持更有效的研究进行。 密歇根州先天性心脏病中心的参与和领导将促进PHN的持续成功， 并使网络能够继续应对当前医疗保健和研究环境的挑战 促进儿科和先天性心血管疾病的治疗和结局。

项目成果

Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up.

• DOI: 10.1007/s00246-023-03216-8
• 发表时间: 2023-10
• 期刊: PEDIATRIC CARDIOLOGY
• 影响因子: 1.6
• 作者: Detterich, Jon D.;Taylor, Michael C.;Slesnick, Timothy;DiLorenzo, Michael;Hlavacek, Anthony;Lam, Christopher Z.;Sachdeva, Shagun;Lang, Sean M.;Campbell, M. Jay;Gerardin, Jennifer;Whitehead, Kevin K.;Rathod, Rahul H.;Cartoski, Mark;Menon, Shaji;Trachtenberg, Felicia;Gongwer, Russell;Newburger, Jane;Goldberg, Caren L.;Dorfman, Adam
• 通讯作者: Dorfman, Adam