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CONTINUOUS 21 DAY INFUSION OF TOPOTECAN IN CHILDREN WITH RELAPSED SOLID TUMORS

CONTINUOUS 21 DAY INFUSION OF TOPOTECAN IN CHILDREN WITH RELAPSED SOLID TUMORS
患有复发性实体瘤的儿童连续 21 天输注拓扑替康
批准号：
6244708
负责人：
RAYMOND J HUTCHINSON
金额：
$2.22万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-20 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6244708
关键词：
child (0-11) clinical research drug administration rate /duration drug screening /evaluation human subject human therapy evaluation injection /infusion leukemia neoplasm /cancer chemotherapy neoplasm /cancer relapse /recurrence pediatric neoplasm /cancer pediatric pharmacology topotecan

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中文摘要
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英文摘要
The objective of this protocol is to determine a safe dose of a 21-day continuous infusion of topotecan administered to children with relapsed solid tumors and no bone marrow involvement. This dose will then be used in a phase-II trial in children with relapsed leukemia and possibly in children with relapsed solid tumors. If active in leukemia as a single agent, topotecan will probably have its major use in maintenance therapy. Severe myelosuppression should be avoided during maintenance treatment. Therefore, the pediatric MTD must be found in patients without bone marrow disease. This MTD would allow future studies of this schedule in children with leukemia or solid tumors.
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Effect of recipient age /graft vs host disease post BMT
VACCINE THERAPY OF PEDIATRIC MALIGNANCIES UTILIZING DENDRITIC CELLS
VACCINE THERAPY OF PEDIATRIC MALIGNANCIES UTILIZING DENDRITIC CELLS
CONTINUOUS 21 DAY INFUSION OF TOPOTECAN IN CHILDREN WITH RELAPSED SOLID TUMORS
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