VASOCONSTRICTION DURING COLD PRESSOR TEST--ALPHA ADRENERGIC BLOCKADE

冷加压试验期间的血管收缩--α肾上腺素能阻断

• 批准号: 6245394
• 负责人: STEVEN FRANK
• 金额: $ 2.23万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-05 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245394
• 关键词: alpha adrenergic agent; cardiovascular pharmacology; clinical research; cold temperature; heart rate; human subject; phentolamine; vasoconstriction

Over the last 3 years since the study has begun we have completed the portion of the study addressing alpha-antagonists and the response to the cold pressor test. The data show that the peripheral vasoconstriction response is attenuated by phentolamine. These results have been previously published (in 1994) and were included in last years GCRC report. The GCRC grant was acknowledged in these abtracts and papers. The other aim in this study was to assess the effects of alpha- adrenergic antagonism on the vasomotor and metabolic mechanisms that maintain norniothermia in the absence of cold stress. These studies were also completed and were published in abstract as well as manuscript form. The findings indicate that alpha-antagonists decrease vasomotor tone, increase heat loss through the skin, which results in a lower core temperature. There is also a dose-response that we have shown for these effects. One additional area of interest was that of heart rate variability. Working with Lee Fleisher in the Dept. of Anesthesiology, we were able to describe the effects of core hypothermia on changes in heart rate variability in human subjects. We showed increased low frequency power in the spectral analysis for R to R interval variability.

自研究开始以来的过去3年中，我们完成了 研究的一部分涉及α-拮抗剂和对α-拮抗剂的反应 冷加压试验 数据显示， 酚妥拉明可减弱血管收缩反应。 这些结果 以前曾出版过（1994年），并在去年被列入 GCRC报告。 在这些摘要中确认了GCRC赠款， 报纸 本研究的另一个目的是评估α- 肾上腺素能拮抗作用的血管和代谢机制， 在没有冷应激的情况下维持正常体温。 这些研究 也完成了，并发表了摘要以及手稿 form. 研究结果表明，α-受体拮抗剂降低血管紧张素转换酶， 色调，增加通过皮肤的热量损失，从而导致较低的核心 温度 我们还发现了这些药物的剂量反应 方面的影响. 另一个感兴趣的领域是心率变异性。 与李·弗莱登斯在部门工作。我们能够 描述核心低温对心率变化的影响 人类受试者的变异性。 我们发现低频功率增加 在R到R间隔变异性的频谱分析中。