Training Program in Cardiovascular Pharmacology

心血管药理学培训计划

• 批准号: 7214832
• 负责人: Joey V. Barnett
• 金额: $ 25.32万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7214832
• 关键词: Training Programs; cardiovascular pharmacology

DESCRIPTION (provided by applicant): The integration of our scientific knowledge of cardiovascular function at the molecular, cellular, and organismal levels is critical to impacting cardiovascular disease in humans. As our insight into molecular and cellular processes has grown, emphasis in many Ph.D. training programs has shifted away from integrated (whole animal or systems) biology. The lack of an available scientific workforce with an understanding of integrated biology, including drug metabolism and pharmacokinetics, and an appreciation of the unique challenges of working in intact organisms will delay the application of discoveries at the molecular and cellular levels to human disease. This training program addresses a critical need for scientists trained in the integrated biology of the cardiovascular system. Our program uses existing strengths in the Department of Pharmacology at Vanderbilt University and key collaborators who direct well established research programs in cardiovascular pharmacology and biology. The primary activity of trainees is research training on issues related to cardiovascular function and disease under the direction of an individual faculty mentor. The usual duration of training is 2-3 years and fellows with Ph.D. and M.D. degrees will be supported. Research training is supplemented with focused didactic lectures on drug metabolism and pharmacokinetics, cardiovascular physiology, and cardiovascular pharmacology (all part of the existing core curriculum of the Predoctoral Pharmacology Training Program). Fellows will be required to participate in Responsibility in Research training and weekly seminar series in Experimental Therapeutics, Cardiovascular Medicine, and Pharmacology. Trainees may elect to participate in the Vanderbilt Master of Science in Clinical Investigation Program. Our specific goals are to provide trainees with expertise in the integrated biology of the cardiovascular system, encourage collaboration between laboratories using whole animal and molecular approaches, and develop scientists trained to participate in drug discovery and drug development in the cardiovascular system. Our overall goal is to train scientists who will be leaders in academia, industry, or regulatory affairs.

描述（由申请人提供）： 在分子、细胞和有机体水平上整合心血管功能的科学知识对于影响人类心血管疾病至关重要。随着我们对分子和细胞过程的了解不断加深，许多博士强调。培训项目已经不再是综合（整个动物或系统）生物学。 由于缺乏了解综合生物学（包括药物代谢和药代动力学）以及了解在完整生物体中工作的独特挑战的可用科学队伍，将延迟分子和细胞水平的发现在人类疾病中的应用。 该培训计划满足了接受过心血管系统综合生物学培训的科学家的迫切需求。 我们的项目利用范德比尔特大学药理学系的现有优势以及指导心血管药理学和生物学方面完善的研究项目的主要合作者。 学员的主要活动是在个别教师导师的指导下进行与心血管功能和疾病相关问题的研究培训。 通常培训期限为2-3年，具有博士学位的研究员。和医学博士学位将得到支持。研究培训辅以有关药物代谢和药代动力学、心血管生理学和心血管药理学的重点教学讲座（所有这些都是博士前药理学培训计划现有核心课程的一部分）。 研究员将被要求参加研究责任培训和每周一次的实验治疗学、心血管医学和药理学研讨会系列。学员可以选择参加范德比尔特临床研究理学硕士项目。 我们的具体目标是为学员提供心血管系统综合生物学方面的专业知识，鼓励实验室之间使用整体动物和分子方法进行合作，并培养受过培训的科学家参与心血管系统的药物发现和药物开发。 我们的总体目标是培养成为学术界、工业界或监管事务领导者的科学家。