Training Program in Cardiovascular Pharmacology

描述(由申请人提供)： 我们在分子、细胞和机体水平上对心血管功能的科学知识的整合对于影响人类的心血管疾病至关重要。随着我们对分子和细胞过程的洞察力的增长，许多博士培训计划的重点已经从整合(整个动物或系统)生物学转移。缺乏一支了解包括药物代谢和药代动力学在内的综合生物学的现有科学队伍，以及认识到在完整生物体中工作的独特挑战，将推迟在分子和细胞层面上将发现应用于人类疾病。这一培训计划满足了对受过心血管系统综合生物学培训的科学家的迫切需求。我们的计划利用了范德比尔特大学药理学系现有的优势和指导心血管药理学和生物学方面成熟研究计划的关键合作者。 学员的主要活动是在个别教员导师的指导下，就与心血管功能和疾病有关的问题进行研究培训。通常的培训期限为2-3年，拥有博士和医学博士学位的研究员将得到支持。研究培训的补充是集中讲授药物代谢和药代动力学、心血管生理学和心血管药理学(所有这些都是博士前药理学培训计划现有核心课程的一部分)。研究员将被要求参加实验治疗学、心血管医学和药理学的研究培训和每周研讨会系列的责任。学员可以选择参加范德比尔特临床研究理学硕士项目。 我们的具体目标是为学员提供心血管系统综合生物学方面的专业知识，鼓励实验室之间使用整体动物和分子方法进行合作，并培养受过培训的科学家，参与心血管系统的药物发现和药物开发。我们的总体目标是培养将成为学术界、工业界或监管事务领导者的科学家。

DESCRIPTION (provided by applicant): The integration of our scientific knowledge of cardiovascular function at the molecular, cellular, and organismal levels is critical to impacting cardiovascular disease in humans. As our insight into molecular and cellular processes has grown, emphasis in many Ph.D. training programs has shifted away from integrated (whole animal or systems) biology. The lack of an available scientific workforce with an understanding of integrated biology, including drug metabolism and pharmacokinetics, and an appreciation of the unique challenges of working in intact organisms will delay the application of discoveries at the molecular and cellular levels to human disease. This training program addresses a critical need for scientists trained in the integrated biology of the cardiovascular system. Our program uses existing strengths in the Department of Pharmacology at Vanderbilt University and key collaborators who direct well established research programs in cardiovascular pharmacology and biology. The primary activity of trainees is research training on issues related to cardiovascular function and disease under the direction of an individual faculty mentor. The usual duration of training is 2-3 years and fellows with Ph.D. and M.D. degrees will be supported. Research training is supplemented with focused didactic lectures on drug metabolism and pharmacokinetics, cardiovascular physiology, and cardiovascular pharmacology (all part of the existing core curriculum of the Predoctoral Pharmacology Training Program). Fellows will be required to participate in Responsibility in Research training and weekly seminar series in Experimental Therapeutics, Cardiovascular Medicine, and Pharmacology. Trainees may elect to participate in the Vanderbilt Master of Science in Clinical Investigation Program. Our specific goals are to provide trainees with expertise in the integrated biology of the cardiovascular system, encourage collaboration between laboratories using whole animal and molecular approaches, and develop scientists trained to participate in drug discovery and drug development in the cardiovascular system. Our overall goal is to train scientists who will be leaders in academia, industry, or regulatory affairs.