ISOLATION/CHARACTERIZATION OF PROSTAGLANDIN SYNTHASE ISOFORMS IN PRETERM LABOR

早产中前列腺素合成酶异构体的分离/表征

• 批准号: 6246093
• 负责人: SUSAN F TOWNSEND
• 金额: $ 1.71万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246093
• 关键词: human tissue; isozymes; premature labor; prostaglandin endoperoxide synthase; protein isoforms; tocolytic agents

PI plans to isolate native human isoforms of PGS from (hPGS-1) normal labor tissues and (hPGS-2) infection induced tissues to sceen specific tocolytics for use in preterm labor intervention. Also, hPGS-1 and hPGS-2 quantitation in intrauterine tissues and comparison with normal laboring tissues will allow for identification of the most active tissue sites of PGS isoform production.

PI计划从（hPGS-1）正常人中分离PGS的天然人同种型 分娩组织和（hPGS-2）感染诱导的组织特异性地 用于早产干预的宫缩抑制剂。 此外，hPGS-1和 子宫内膜组织中hPGS-2的定量及其与正常子宫内膜组织的比较 劳动组织将允许识别最活跃的组织 PGS同种型生产的位点。