INHALED STEROIDS TO PREVENT CHRONIC LUNG DISEASE IN INTUBATED PREMATURE INFANTS

吸入类固醇预防插管早产儿的慢性肺病

• 批准号: 6114944
• 负责人: SUSAN F TOWNSEND
• 金额: $ 1.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114944
• 关键词: chemoprevention; clinical research; drug adverse effect; human subject; human therapy evaluation; inhalation drug administration; intravenous administration; premature infant human; respiratory distress syndrome of newborn; respiratory therapy; steroids

This study will determine whether early treatment of intubated extremely low birthweight premature infants with respiratory distress with inhaled steroids will diminish the use of more toxic therapy with high-dose intravenous steroids; and whether such treatment will shorten the duration of mechanical ventilation and decrease the incidence of chronic lung disease. Safety of therapy with inhaled steroids will be evaluated and compared to treatment with intravenous steroids.

本研究将确定早期使用吸入类固醇治疗气管插管的极低出生体重早产儿呼吸窘迫是否会减少使用毒性更大的静脉注射类固醇治疗；是否会缩短机械通气时间，降低慢性肺部疾病的发生率。将评估吸入类固醇治疗的安全性，并将其与静脉注射类固醇治疗进行比较。