EVALUATION OF CONTINUOUS INFUSION GALLIUM NITRATE FOR ADVANCED BLADDER CARCINOMA

连续输注硝酸镓治疗晚期膀胱癌的评估

• 批准号: 6246367
• 负责人: ERIC J SMALL
• 金额: $ 4.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-04 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246367
• 关键词: bladder neoplasm; carcinoma; clinical research; drug administration rate /duration; drug adverse effect; drug screening /evaluation; gallium; human subject; human therapy evaluation; neoplasm /cancer chemotherapy; neoplasm /cancer relapse /recurrence; neoplastic process; nitrates

The investigators plan to: 1) Assess the efficacy and feasibility of utilizing gallium nitrate in patients who have progressed following cytotoxic chemotherapy with advanced or recurrent urothelial tract tumors, and 2) Evaluate the toxicity of gallium nitrate in this group of patients. The gallium nitrate is to be given by continuous infusion over 24 hrs for 7 consecutive days at start of each treatment cycle in the amount of 300 mg/m2/day. Patient must be hospitalized for first treatment cycle.

研究人员计划：1)评估药物的有效性和可行性 随访进展患者应用硝酸镓的临床研究 晚期或复发尿路上皮行细胞毒性化疗 2)评估硝酸镓对这组人的毒性。 病人。硝酸镓是通过持续输液给药的。 在每个治疗周期开始时连续7天24小时 剂量300毫克/平方米/天。病人必须先住院 治疗周期。