Prostate Cancer Program

前列腺癌计划：摘要/摘要 HDfccc前列腺癌(PR)计划的首要科学目标是使用团队方法来 促进对肿瘤生物学的理解，推动转化为更有效和更有针对性的治疗。 这是通过从发现实验室科学到临床应用再到临床应用的转化性研究来完成的。 公关计划还寻求具体解决前列腺癌的负担和预后差异 在集水区内的患者中。其结果将是降低相关的发病率和死亡率 前列腺癌及其治疗通过利用对疾病的深入了解在生物学上， 临床和人口水平。公关计划通过跨学科的研究来实现这一使命，即 高度协作和翻译，围绕三个具体目标组织：(1)发现分子特征 和前列腺癌的驱动因素；(2)开发和验证预测男性预后的生物标记物和模型 前列腺癌；以及(3)开发临床干预措施，以改善前列腺癌患者的预后 癌症。

Prostate Cancer Program: Summary/Abstract The overarching scientific goal of the HDFCCC Prostate Cancer (PR) Program is to use a team approach to advance the understanding of tumor biology and drive translation into more effective and targeted treatment. This is done through translational research spanning discovery bench science to clinical application and back. The PR Program also seeks to specifically address the burden of prostate cancer and disparities in outcomes among patients within the catchment area. The result will be a reduction the morbidity and mortality associated with prostate cancer and its treatments by leveraging a deep understanding of the disease at the biologic, clinical, and population levels. The PR Program approaches this mission with transdisciplinary research that is richly collaborative and translational, organized around three specific aims: (1) to discover molecular features and drivers of prostate cancer; (2) to develop and validate biomarkers and models to predict outcomes in men with prostate cancer; and (3) to develop clinical interventions to improve outcomes for men with prostate cancer.