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STUDY OF PYRAZOLOACRIDINE FOR TREATMENT OF HORMONE REFRACTORY PROSTATE CANCER

STUDY OF PYRAZOLOACRIDINE FOR TREATMENT OF HORMONE REFRACTORY PROSTATE CANCER
吡唑吖啶治疗激素难治性前列腺癌的研究
批准号：
5219067
负责人：
ERIC J SMALL
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5219067
关键词：
acridines antineoplastics clinical research drug adverse effect human old age (65+) human subject human therapy evaluation male neoplasm /cancer chemotherapy neoplasm /cancer remission /regression pain pharmacokinetics prostate neoplasms prostate specific antigen quality of life questionnaires

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英文摘要
We propose to evaluate the efficacy of PZ in treatment of hormone refractory prostate cancer. Objectives are: to evaluate response rate of pts with chemotherapy naive cancer by changes in PSA and other measurements of disease activity when treated with PZ. To evaluate impact of quality of life and pain control using questionnaires. To describe toxicity profile of PZ in a uniform, older patient population. To describe overall and progression free survival. To describe population pharmacokinetic variable.
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