A novel interaction between the immune and vascular systems in early-onset preeclampsia; an opportunity for new treatments?

早发性先兆子痫中免疫系统和血管系统之间的新型相互作用；

• 批准号: nhmrc : 2002129
• 金额: $ 92.16万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/a-novel-interaction-new-treatments/1779849
• 关键词: novel; interaction; between; immune; vascular

Preeclampsia is a pregnancy complication that leads to poor birth outcomes and elevated lifelong cardiovascular disease risk in 4 million women each year. It has no cure and treatments are limited because the causal mechanisms are not understood. We have identified a specialised immune cell in the mother's blood that assists blood vessels to function properly in pregnancy. We will assess whether interventions to enhance these cells can improve poor blood vessel function and pregnancy outcomes.

先兆子痫是一种妊娠并发症，每年导致400万妇女的不良出生结局和终身心血管疾病风险升高。它无法治愈，治疗方法有限，因为因果机制尚不清楚。我们已经在母亲的血液中发现了一种特殊的免疫细胞，它可以帮助血管在怀孕期间正常运作。我们将评估增强这些细胞的干预措施是否可以改善不良的血管功能和妊娠结局。