MOLECULAR GENETICS OF MENTAL DISORDER

在惊恐障碍项目中，已经收集了21个多基因家系 并为200多个RFLP标记打字。人类多发性硬化候选基因研究 肾上腺素能受体基因座也已完成。下一个目标将是 在接下来的三年里，每年增加五个系谱，并输入300- 覆盖整个人类基因组的500个短串联重复标记。 在精神分裂症项目上，已经完成了15个多重家系 另外两个将在短期内完成。三个感兴趣的地区 检查是否有连锁，没有检测到易感基因座。这些 区域包括染色体5q11-q13、11q和假常染色体区域 性染色体。下一个目标是每个人增加三个家系 在接下来的三年里，研究感兴趣的基因组区域 候选基因，并将这些家系与其他群体的家系汇集在一起 一次合作的基因组搜索。

On the panic disorder project 21 multiplex pedigrees have been collected and typed for over 200RFLP markers. A candidate gene study of the adrenergic receptor loci was also completed. The next objectives will be to add five pedigrees per year over the next three years, and to type 300- 500 short tandem repeat markers covering the entire human genome. On the schizophrenia project, 15 multiplex pedigrees have been completed and two more will be completed shortly.Three regions of interest have been examined for linkage and no vulnerability loci were detected. These regions include chromosome 5q11-q13, 11q, and the pseudoautosomal region of the sex chromosomes. The next objectives are to add three pedigrees per year for the next three years, to study genomic regions of interest and candidate genes, and to pool the pedigrees with those of other groups in a collaborative genome search.