课题基金 / 基金详情

VIROLOGY AND GENETICS OF CANCER

VIROLOGY AND GENETICS OF CANCER
癌症病毒学和遗传学
批准号:
2894478
负责人:
HILARY KOPROWSKI
金额:
$116.08万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-08-18 至 2001-05-31

项目摘要

项目成果

HILARY KOPROWSKI的其他基金

相关文献

中文摘要
翻译
分子导向的病毒学和遗传学研究越来越多
英文摘要
Increasingly molecularly oriented virology and genetic studies in this program of the last fifteen years have brought us to the point that our main theme in this revised renewal program is to use molecular techniques in virology and genetics to define a series of critical genes, at which genetic lesions in cancer cells have led to dysregulation of growth control. Our overall goal in the renewal program is to understand the normal function of these critical genes, and how their alterations leads to neoplasia or other abnormality, so that pharmacological or genetic methods to intervene can be devised and tested, to provide a basis for therapeutic intervention. Project 1 will define and characterize genes activated by proviral insertion that result in myeloid leukemia; the first gene characterized by the project is a novel member of a homebox gene subfamily. This subfamily is defined by PBX1, a gene involved in chromosome translocation resulting in human Pre B cell leukemia. Project 2 will characterize a gene expressed in embryonic hematopoietic stem cells, investigate its role in hematopoietic differentiation and function as a stem cell marker. Project 3 will identify and characterize melanoma tumor suppressor gene(s) in chromosome region 9p21 and study function in normal and malignant cells; the dual approach will involve characterization of the role of the p16 gene in familial melanoma in three kindreds and identification of another 9p21 suppressor gene, likely to have a direct role in several forms of neoplasia. project 4, a new project in this revision, aims to clone and characterize the gene involved in the lethal spotting (Is mutation, a murine, a murine disease similar to human Hirschsprung's disease; one form of Hirschsprung's disease is known to involve the RET oncogene which is involved in several familial neoplasias. Each of the projects involves cloning and characterization of genes with critical roles in growth, differentiation or neoplasia. Expression and functional studies, as well as gene mapping, for each of these cloned loci will be performed through interactions among the projects, taking maximum advantage of the cost, technology, expertise and idea-sharing promoted by the Program Project structure.
期刊论文(221)
专著(0)
科研奖励(0)
会议论文
DOI: --
发表时间: 1993-07
期刊: Oncogene
影响因子: 8
作者: [Luca Tamagnone;Juha Partanen;E. Armstrong;Jerzy Lasota;Kinya Ohgami;Tetsushi Tazunoki;S. Laforgia-S.-La]
通讯作者: Luca Tamagnone;Juha Partanen;E. Armstrong;Jerzy Lasota;Kinya Ohgami;Tetsushi Tazunoki;S. Laforgia-S.-La
Monoclonal antibodies as applied to tumor-associated antigens: the CO17-1A antigen.
应用于肿瘤相关抗原的单克隆抗体:CO17-1A 抗原。
DOI: --
发表时间: 1989
期刊: Immunology series
影响因子: --
作者: [Ross,AH, Herlyn,D, Steplewski,Z, Koprowski,H]
通讯作者: Koprowski,H
Identical D region sequences expressed by murine monoclonal antibodies specific for a human tumor-associated antigen.
由针对人类肿瘤相关抗原的鼠单克隆抗体表达的相同 D 区序列。
DOI: --
发表时间: 1990
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者: [Caton,AJ, Herlyn,D, Ross,AH, Koprowski,H]
通讯作者: Koprowski,H
The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers.
FHIT 基因在胰腺导管细胞中表达,并在胰腺癌中发生改变。
DOI: --
发表时间: 1999
期刊: Cancer research
影响因子: 11.2
作者: [Sorio,C, Baron,A, Orlandini,S, Zamboni,G, Pederzoli,P, Huebner,K, Scarpa,A]
通讯作者: Scarpa,A
154
    Approach to control caries through apple-derived vaccine
    • 批准号:
      7135549
    • 项目类别:
    • 资助金额:
      $15.14万
    • 财政年份:
      2005
    • 负责人:
      HILARY KOPROWSKI
    • 依托单位:
    Approach to control caries through apple-derived vaccine
    • 批准号:
      6967247
    • 项目类别:
    • 资助金额:
      $26.17万
    • 财政年份:
      2005
    • 负责人:
      HILARY KOPROWSKI
    • 依托单位:
    NEWLY EMERGING RABIES VIRUS VARIANTS
    • 批准号:
      2766677
    • 项目类别:
    • 资助金额:
      $32.39万
    • 财政年份:
      1999
    • 负责人:
      HILARY KOPROWSKI
    • 依托单位:
    NEWLY EMERGING RABIES VIRUS VARIANTS
    • 批准号:
      6170471
    • 项目类别:
    • 资助金额:
      $33.36万
    • 财政年份:
      1999
    • 负责人:
      HILARY KOPROWSKI
    • 依托单位: