REAGENT RESOURCE SUPPORT FOR AIDS VACCINE DEVELOPMENT

艾滋病疫苗研发的试剂资源支持

• 批准号: 2656533
• 负责人: RONALD BROWN
• 金额: $ 80万
• 依托单位: QUALITY BIOLOGICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-12-23 至 2002-12-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2656533
• 关键词: AIDS; AIDS vaccines; biomedical registry /referral center; human immunodeficiency virus; hybridomas; microorganism resource /registry; molecular cloning; monoclonal antibody; reagent /indicator; simian immunodeficiency virus

The objectives of this contract focus on the production, procurement, quality assessment, and distribution of research reagents in support of DAIDS-funded HIV vaccine development. 1 - Acquire by purchase or other arrangement and then characterize quantities of viral gene products (e.g., HIV-1, SIV) for distribution for use by DAIDS-supported investigators. 2- Acquire and characterize immunologic adjuvants, immunomodulators, and vaccine delivery systems for use in experimental HIV vaccine formulations. 3- Generate working quantities of specialized viral gene products or other reagents not readily available through purchase. 4- Clone retroviral genes into appropriate prokaryotic expression vectors and perform quality assurance testing of these vectors and genes as required by the Project Officer. 5- Prepare and characterize hybridomas and monoclonal antibodies as required by the Project Officer. 6- Maintain an electronic inventory of reagents and stock and a database of all reagent analysis results. 7- Maintain and distribute all stocks and reagents as required and keep a tracking system in which any given sample can be traced from receipt through processing, storage and distribution.

该合同的目标集中在生产，采购， 质量评估和分发研究试剂，以支持 DAIDS资助的艾滋病毒疫苗开发。 1 -通过购买或其他安排获得，然后描述 病毒基因产物的量（例如，艾滋病毒1型、SIV型），用于分发给 由DAIDS支持的调查人员使用。 2-获取和表征免疫佐剂、免疫调节剂和 用于实验性HIV疫苗制剂的疫苗递送系统。 3-产生工作量的专门病毒基因产物或其他 试剂不容易通过购买获得。 4-将逆转录病毒基因克隆到合适的原核表达载体中 并对这些载体和基因进行质量保证测试， 项目负责人要求。 5-制备并表征杂交瘤和单克隆抗体， 项目负责人要求。 6-维护试剂和库存的电子库存和数据库 所有试剂分析结果。 7-根据需要维护和分发所有库存和试剂， 跟踪系统，其中任何给定的样品可以从接收跟踪 通过加工、储存和分配。