Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccines Research a

非人类灵长类艾滋病疫苗研究核心功能基因组学实验室

• 批准号: 8748807
• 负责人: MICHAEL G KATZE
• 金额: $ 256.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8748807
• 关键词: AIDS Vaccines; Algorithms; Bioinformatics; Biological Assay; Combined Vaccines; Contracts; Data; Enrollment; Genes; Genomics; Grant; Immune response; Immunization; Infection; Infection prevention; Laboratories; Methods; Modeling; Molecular Profiling; National Institute of Allergy and Infectious Disease; Pathway Analysis; Protocols documentation; RNA; Research Personnel; Risk; Route; Sampling; Services; Testing; Vaccine Research; Vaccines; Virus; Virus Replication; biocomputing; design; functional genomics; neutralizing antibody; nonhuman primate; programs; tool; transcriptomics; vaccine delivery; vaccine efficacy; vaccine evaluation

Nonhuman primate (NHP) models present the opportunity to test a variety of candidate AIDS vaccines, optimizing their ability to elicit immune responses and testing their ability to prevent infection or to control virus replication after virus challenge. NHP models can be used to optimize vaccines, to evaluate vaccine combinations, to determine vaccine delivery routes that provide immune responses at mucosal portals of entry, to find ways to generate broadly cross-reactive neutralizing antibodies, and, following challenge with virus, to determine whether or not the vaccine immunizations were effective. NHP models can also be used to explore a vaccine¿s impact on the risk of acquisition of infection. NIAID supports NHP studies through both contract (Simian Vaccine Evaluation Unit contracts) and grant assistance mechanisms.

非人灵长类动物（NHP）模型提供了测试各种候选艾滋病疫苗的机会，优化其引发免疫反应的能力，并测试其预防感染或在病毒攻击后控制病毒复制的能力。NHP模型可用于优化疫苗，评估疫苗组合，确定在粘膜入口提供免疫应答的疫苗递送路线，寻找产生广泛交叉反应的中和抗体的方法，并在病毒攻击后确定疫苗免疫是否有效。NHP模型还可用于探索疫苗对获得感染风险的影响。NIAID通过合同（类人猿疫苗评估单位合同）和赠款援助机制支持NHP研究。