PATHOLOGY SUPPORT FOR THE NTP QUALITY ASSESSMENT

由国家毒理学计划进行的病理学同行评议 (NTP)已成为确保协议有效性的标准手段 在啮齿动物生物检测中产生的病理数据。世界上的大部分 NTP在这方面的努力包含在病理合同中 质量保证。《NTP的病理学支持--质量保证》 (QA)。根据本合同，病理材料(幻灯片、图块等)是 对质量(染色等)进行评估和完整性(滑行、拦网比赛、 组织的存在等)。另外，大多数人的病理诊断- 在以下实验室进行的内部研究和所有NTP研究 NTP的合同由另一名病理学家核实。目前， 病理表以电子方式接收并格式化，以供 QA病理学家。研究中的病理学家和 QA病理学家在提交的QA叙述中被突出显示 以及给NTP的幻灯片。差异通过以下方式进行评估 病理工作组(PWG)主席，负责 选择有代表性的案例进行PWG审查。QA病理学家和 其他专家参加PWG同行审查，其中选定的案例 在不知道研究或QA病理学家诊断的情况下进行检查。

Pathology peer review as carried out by the Natioal Toxicology Program (NTP) has become a standard means of assuring the validity of the pathology data generated in the rodent bioassays. A major portion of the NTP effort in this regard is contained in the contract for pathology quality assurance. "Pathology support for the NTP-Quality Assurance" (QA). Under this contract, pathology materials (slides, blocks, etc.) are evaluated for quality (staining, etc.) and integrity (slide, block match, presence of tissues, etc.). Also, the pathology diagnosis for most in- house studies and all NTP studies carried out in the laboratories under contract to the NTP are verified by a second pathologist. Currently, the pathology tables are received electronically and formatted for use by the QA pathologists. All discrepancies between the study pathologist and the QA pathologists are highlighted in a QA narrative which is submitted together with the slides to the NTP. The discrepancies are evaluated by the Pathology Working Group (PWG) chairperson who is responsible for selecting representative cases for PWG review. The QA Pathologist and other Experts participate in the PWG Peer Review where selected cases are examined without knowing either the study or QA Patholgists diagnosis.