PATHOLOGY SUPPORT FOR THE NTP QUALITY ASSESSMENT

由国家毒理学计划（NTP）开展的病理同行评议已成为确保啮齿动物生物测定中产生的病理数据有效性的标准手段。国家结核控制规划在这方面的主要工作内容包含在病理质量保证合同中。“ntp质量保证的病理支持”（QA）。根据本合同，对病理材料（载玻片、切片等）的质量（染色等）和完整性（载玻片、切片匹配、组织存在等）进行评估。此外，大多数内部研究的病理诊断和所有国家毒理学控制项目在与国家毒理学控制项目签订合同的实验室进行的研究都由第二位病理学家进行验证。目前，病理表以电子方式接收，并格式化供QA病理学家使用。研究病理学家和QA病理学家之间的所有差异都在QA叙述中突出显示，该叙述与幻灯片一起提交给NTP。差异由病理工作组（PWG）主席评估，他负责选择具有代表性的病例供PWG审查。QA病理学家和其他专家参与PWG同行评审，在不知道研究或QA病理学家诊断的情况下检查选定的病例。

Pathology peer review as carried out by the Natioal Toxicology Program (NTP) has become a standard means of assuring the validity of the pathology data generated in the rodent bioassays. A major portion of the NTP effort in this regard is contained in the contract for pathology quality assurance. "Pathology support for the NTP-Quality Assurance" (QA). Under this contract, pathology materials (slides, blocks, etc.) are evaluated for quality (staining, etc.) and integrity (slide, block match, presence of tissues, etc.). Also, the pathology diagnosis for most in- house studies and all NTP studies carried out in the laboratories under contract to the NTP are verified by a second pathologist. Currently, the pathology tables are received electronically and formatted for use by the QA pathologists. All discrepancies between the study pathologist and the QA pathologists are highlighted in a QA narrative which is submitted together with the slides to the NTP. The discrepancies are evaluated by the Pathology Working Group (PWG) chairperson who is responsible for selecting representative cases for PWG review. The QA Pathologist and other Experts participate in the PWG Peer Review where selected cases are examined without knowing either the study or QA Patholgists diagnosis.