PATHOLOGY SUPPORT FOR THE NTP QUALITY ASSESSMENT

NTP 质量评估的病理学支持

• 批准号: 6055235
• 负责人: PETER MANN
• 金额: $ 174.79万
• 依托单位: EXPERIMENTAL PATHOLOGY LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6055235
• 关键词: PATHOLOGY; SUPPORT; NTP; QUALITY; ASSESSMENT

Pathology peer review as carried out by the Natioal Toxicology Program (NTP) has become a standard means of assuring the validity of the pathology data generated in the rodent bioassays. A major portion of the NTP effort in this regard is contained in the contract for pathology quality assurance. "Pathology support for the NTP-Quality Assurance" (QA). Under this contract, pathology materials (slides, blocks, etc.) are evaluated for quality (staining, etc.) and integrity (slide, block match, presence of tissues, etc.). Also, the pathology diagnosis for most in- house studies and all NTP studies carried out in the laboratories under contract to the NTP are verified by a second pathologist. Currently, the pathology tables are received electronically and formatted for use by the QA pathologists. All discrepancies between the study pathologist and the QA pathologists are highlighted in a QA narrative which is submitted together with the slides to the NTP. The discrepancies are evaluated by the Pathology Working Group (PWG) chairperson who is responsible for selecting representative cases for PWG review. The QA Pathologist and other Experts participate in the PWG Peer Review where selected cases are examined without knowing either the study or QA Patholgists diagnosis.

由国家毒理学计划（NTP）进行的病理学同行评审已成为确保啮齿动物生物测定中生成的病理学数据有效性的标准方法。 国家结核病规划署在这方面的努力的主要部分载于病理学质量保证合同。 “NTP-质量保证的病理学支持”（QA）。 根据该合同，病理材料（载玻片、块等）评价质量（染色等）和完整性（载玻片、组织块匹配、存在组织等）。 此外，大多数内部研究和在与NTP签订合同的实验室中进行的所有NTP研究的病理学诊断均由第二名病理学家进行验证。 目前，病理学表格以电子方式接收并格式化，供QA病理学家使用。 研究病理学家和QA病理学家之间的所有差异均在QA叙述中突出显示，该叙述与切片一起提交给NTP。 由病理学工作组（PWG）主席评价差异，PWG主席负责选择代表性病例进行PWG审查。 QA病理学家和其他专家参与PWG同行评审，在不了解研究或QA病理学家诊断的情况下对选定病例进行检查。