PATHOLOGY SUPPORT FOR THE NTP QUALITY ASSESSMENT

NTP 质量评估的病理学支持

• 批准号: 6324311
• 负责人: PETER MANN
• 金额: --
• 依托单位: EXPERIMENTAL PATHOLOGY LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6324311
• 关键词: cellular pathology; diagnosis design /evaluation; diagnosis quality /standard; evaluation /testing; histopathology; pathology; toxicant screening

Pathology peer review as carried out by the Natioal Toxicology Program (NTP) has become a standard means of assuring the validity of the pathology data generated in the rodent bioassays. A major portion of the NTP effort in this regard is contained in the contract for pathology quality assurance. "Pathology support for the NTP-Quality Assurance" (QA). Under this contract, pathology materials (slides, blocks, etc.) are evaluated for quality (staining, etc.) and integrity (slide, block match, presence of tissues, etc.). Also, the pathology diagnosis for most in- house studies and all NTP studies carried out in the laboratories under contract to the NTP are verified by a second pathologist. Currently, the pathology tables are received electronically and formatted for use by the QA pathologists. All discrepancies between the study pathologist and the QA pathologists are highlighted in a QA narrative which is submitted together with the slides to the NTP. The discrepancies are evaluated by the Pathology Working Group (PWG) chairperson who is responsible for selecting representative cases for PWG review. The QA Pathologist and other Experts participate in the PWG Peer Review where selected cases are examined without knowing either the study or QA Patholgists diagnosis.

由国家毒理学计划进行的病理学同行评审 (NTP)已成为确保法律有效性的标准手段， 啮齿动物生物测定中产生的病理学数据。 的主要部分 NTP在这方面的努力包含在病理学合同中 质量保证。 “NTP的病理学支持-质量保证” （QA）。 根据该合同，病理材料（载玻片、块等）是 质量评价（染色等）和完整性（幻灯片，块匹配， 组织的存在等）。 此外，病理诊断为大多数在- 内部研究和在实验室进行的所有NTP研究， 与NTP的合同由第二位病理学家验证。 目前 病理学表格以电子方式接收并格式化以供 QA病理学家。 研究病理学家和 在提交的QA叙述中突出显示QA病理学家 与载玻片一起送到NTP。 通过以下方式评估差异： 病理学工作组（PWG）主席，负责 选择代表性病例进行PWG审查。 QA病理学家和 其他专家参加PWG同行评审， 在不知道研究或QA病理学家诊断的情况下进行检查。