EFFECTS OF NICOTINE ON NPY FEEDING AND METABOLISM

尼古丁对 NPY 摄食和代谢的影响

• 批准号: 6174615
• 负责人: CHRISTOPHER R BISHOP
• 金额: $ 2.19万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-10 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6174615
• 关键词: Animalia; bioenergetics; eating; neuropeptide Y; nicotine; nicotinic receptors; nutrition related tag; paraventricular nucleus

While there is extensive information on the deleterious effects of smoking on health, approximately 26 percent of Americans continue to smoke. One of the factors mediating onset, continuance and relapse, particularly in women, is its weight-moderating effects. Though it has been demonstrated in animal models, that nicotine, the active ingredient in smoking, produces weight loss and subsequent weight gain following cessation of nicotine administration, mechanisms responsible for this effect have yet to be elucidated. This application proposes experiments designed to identify the role of a potent orexigenic compound, neuropeptide Y (NPY), in these effects. NPY is known to significantly potentiate food intake and biochemical utilization of carbohydrates in animals when injected into the paraventricular nucleus (PVN) of the hypothalamus, and has been recently shown to be altered during nicotine administration. In the proposed experiments, nicotine, administered via Alzet pumps, would be infused for 14 days followed by an abrupt cessation (pump explantation). The proposed set of experiments will identify the differential feeding, metabolic and gender effects of NPY on nicotine over acute, chronic and post-nicotine phases. These techniques will help to characterize the role of NPY in the weight-moderating effects of nicotine as well as how it affects food intake and metabolism.

尽管有有关吸烟对健康的有害影响的广泛信息，但大约26％的美国人继续吸烟。 介导，连续和复发的因素之一，尤其是在女性中，其重量调节作用。 尽管在动物模型中已经证明了这一点，但尼古丁是吸烟中的活性成分，会导致体重减轻，并在停止尼古丁给药后随后的体重增加，但造成这种影响的机制尚未阐明。 该应用程序提出了旨在识别有效的甲状根性化合物神经肽Y（NPY）在这些作用中的作用的实验。 已知NPY可以显着增强食物的摄入量和在下丘脑的副核核（PVN）中注入动物中碳水化合物的生化利用，并且最近已证明在尼古丁给药过程中已改变。 在拟议的实验中，通过Alzet泵施用的尼古丁将被注入14天，然后突然停止（泵外膨胀）。 提出的一组实验将确定NPY对尼古丁对急性，慢性和新核碱阶段的差异喂养，代谢和性别影响。这些技术将有助于表征NPY在尼古丁的重量调节作用中的作用，以及它如何影响食物摄入和代谢。