LONG TERM EFFECTS OF FLUORIDE INGESTION IN ADULTS WITH DIABETES

成人糖尿病患者摄入氟化物的长期影响

• 批准号: 6117805
• 负责人: RICHARD JACKSON
• 金额: $ 1.7万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117805
• 关键词: adult human (21+); blood chemistry; clinical research; diabetes mellitus; diabetes mellitus therapy; drug adverse effect; human subject; human therapy evaluation; ingested fluoride therapy; longitudinal human study; nutrient drug interaction; urinalysis; water supply

Numerous studies have borne out the safety and efficacy of optimally- fluoridated wate in preventing dental caries (Dean, 1954; Johansen et al., 1979, Young et al., 1983, CDC, 1988). Because of its cariostatic properties, fluoride had been increasing added to other delivery systems including dentifrices, mouthrinses, professionally-applied topicals, pediatric supplements, and restorative materials. The widespread, and frequently indiscriminate use of these products has resulted in incresed exposure of the population of fluoride and had raised question regarding the safety of its use. Increasingly vocal concerns from opponents of public water fluoration have raised questions about possible health risks which may result (Hileman, 1988).

许多研究已经证明了最佳的安全性和有效性- 氟化水在预防龋齿中的作用（Dean，1954; Johansen等人， 1979年，Young等人，1983，CDC，1988）。因为它的防龋作用 由于氟化物的性质， 包括牙膏、漱口水、专业外用药， 儿科补充剂和修复材料。 广泛的，和 这些产品的频繁滥用导致了 暴露于氟化物的人口，并提出了问题， 其使用的安全性。 越来越多的反对者表示担忧， 公共水源氟化引起了人们对可能的健康风险的质疑 这可能导致（Hileman，1988）。