GCRC

GCRC

• 批准号: 2884251
• 负责人: DONALD F TAPLEY
• 金额: $ 5.46万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884251
• 关键词: clinical research; human subject

Continuation of the General Clinical Research Center for adult and pediatric patients at the Columbia-Presbyterian Medical Center in New York City and for adult patients at the St. Luke's/Roosevelt Hospital Center Satellite is proposed for the purpose of providing facilities for multidisciplinary intensive bedside and outpatient clinical investigation of human disease. Support is requested for 1500 "A" days (adult inpatient), 200 "A" days (St. Luke's/Roosevelt), a Core Laboratory, a computer based data management and analysis resource, and a metabolic diet kitchen (nutrition unit). The Center is designed so that acutely ill, as well as ambulatory patients can be studied. The Center provides for hospitalization of patients in a setting in which careful dietary control, skillful intensive nursing care, and precise collection of urine, stool and blood specimens, as well as other special procedures, can be carried out. Qualified faculty members of the clinical and basic science departments of the College of Physicians and Surgeons of Columbia University will study clinical problems which embrace most of the major fields of clinical investigation. Although the primary purpose of the facility is concerned with human research, it also provides unusual opportunities for undergraduate and postgraduate training in clinical investigation. Major research activities include: lipid and lipoprotein metabolism, congestive heart failure, atherosclerosis in children and adults, cardiac arrhythmias, AIDS, Alzheimer's disease and other dementias, Parkinson's disease (fetal tissue transplant), stroke, hyperparathyroidism, osteoporosis and other metabolic bone disorders, gene therapy in cancer, ovarian cancer, prostate cancer, mitochondrial encephalomyopathies and mental retardation, obesity, substance abuse/cocaine metabolism, infant nutrition and energy intake, thrombosis, geriatrics/aging, movement disorders, psoriasis, orthopedics, reproductive medicine, attention deficit disorders in children, cardiac denervation and psychophysiological activity, the effects of maternal substance abuse on child development, epidemiology, and obesity and diabetes.

成人和成人综合临床研究中心的延续 位于纽约的哥伦比亚长老会医疗中心的儿科患者 约克市和圣卢克/罗斯福医院的成人患者 中心卫星的目的是提供设施， 多学科密集床旁和门诊临床研究 人类疾病。需要1500个“A”日的支持（成人） 住院病人），200“A”天（圣卢克/罗斯福），一个核心实验室，一个 基于计算机的数据管理和分析资源，以及代谢 饮食厨房（营养单位）。该中心的设计是为了 可以研究生病的以及非卧床的患者。该中心提供 对于住院的病人，在一个环境中， 控制，熟练的重症监护，和精确的收集 尿液、粪便和血液样本，以及其他特殊程序， 可以执行。合格的临床和基础教师 哥伦比亚内外科医学院科学系 大学将研究临床问题，其中包括大部分的主要 临床研究领域。虽然主要目的是 该设施与人类研究有关，它还提供了不寻常的 临床本科生和研究生培训的机会 调查 主要研究活动包括：脂质和脂蛋白代谢， 充血性心力衰竭，儿童和成人动脉粥样硬化，心脏 心律失常，艾滋病，阿尔茨海默氏病和其他痴呆症，帕金森氏症 疾病（胎儿组织移植）、中风、甲状旁腺功能亢进症， 骨质疏松症和其他代谢性骨疾病，癌症的基因治疗， 卵巢癌、前列腺癌、线粒体脑肌病和 精神发育迟滞，肥胖，药物滥用/可卡因代谢，婴儿 营养和能量摄入、血栓形成、老年病/衰老、运动 疾病，牛皮癣，骨科，生殖医学，注意 儿童的缺陷性疾病、心脏去神经支配和 心理生理活动，母亲药物滥用对 儿童发育，流行病学，肥胖症和糖尿病。