EVALUATION OF TOXICITY OF CONTINUOUS NEBULIZED ALBUTEROL IN CHILDREN

持续雾化沙丁胺醇对儿童的毒性评估

• 批准号: 6118738
• 负责人: ROBERT KATZ
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118738
• 关键词: albuterol; bronchodilators; bronchospasm; child (0-11); clinical research; creatine kinase; dosage; drug adverse effect; drug screening /evaluation; electrocardiography; human subject; human therapy evaluation; inhalation drug administration; longitudinal human study; myocardial ischemia /hypoxia; pediatric pharmacology

The purpose of this investigation is to determine if high-dose, continuously nebulized albuterol (CNA) induces clinically significant cardiovascular or metabolic toxicity in infants and young children. We will be testing the hypothesis that CNA does not induce significant toxicity when used in infants and children for severe bronchospasm. This will be a prospective longitudinal case series that will measure cardiac ischemia by enzyme (creatine phosphokinase CK) concentrations as well as electrocardiograms (EKGs).

这项研究的目的是确定大剂量，连续雾化的白化醇（CNA）是否诱导婴儿和幼儿的临床意义心血管或代谢毒性。 我们将测试以下假设：在婴儿和儿童中用于严重的支气管痉挛时，CNA不会诱导明显的毒性。 这将是一个前瞻性纵向病例系列，它将通过酶（肌酸磷酸激酶CK）浓度以及心电图（EKGS）测量心脏缺血。