EVALUATION OF TOXICITY OF CONTINUOUS NEBULIZED ALBUTEROL IN CHILDREN

持续雾化沙丁胺醇对儿童的毒性评估

• 批准号: 5222013
• 负责人: ROBERT KATZ
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5222013
• 关键词: bronchodilators; bronchospasm; child (0-11); clinical research; creatine kinase; dosage; drug adverse effect; drug screening /evaluation; electrocardiography; human subject; human therapy evaluation; inhalation drug administration; longitudinal human study; myocardial ischemia /hypoxia; pediatric pharmacology

The purpose of this investigation is to determine if high-dose, continuously nebulized albuterol (CNA) induces clinically significant cardiovascular or metabolic toxicity in infants and young children. We will be testing the hypothesis that CNA does not induce significant toxicity when used in infants and children for severe bronchospasm. This will be a prospective longitudinal case series that will measure cardiac ischemia by enzyme (creatine phosphokinase CK) concentrations as well as electrocardiograms (EKGs).

这项调查的目的是确定是否高剂量， 连续雾化的白化醇（CNA）诱导临床意义 婴儿和幼儿的心血管或代谢毒性。 我们 将检验以下假设：CNA不会引起显着 当婴儿和儿童用于严重支气管痉挛时的毒性。 这 将是一个前瞻性纵向案例系列，将测量心脏 酶（肌酸磷酸激酶CK）浓度以及 心电图（EKGS）。