PLASMA ARGININE LEVELS IN CRITICALLY ILL PEDIATRIC PATIENTS

危重儿科患者的血浆精氨酸水平

• 批准号: 6118812
• 负责人: ROBERT KATZ
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118812
• 关键词: arginine; biomarker; blood chemistry; child (0-11); clinical research; critical care; human morbidity; human subject; pediatrics

This study will test the hypothesis that plasma arginine levels in critically ill pediatric patients are affected by their severity of illness by measuring plasma arginine levels concurrently with administration of the PRISM III (Pediatric Risk of Mortality) Score. By measuring the correlation between the arginine levels and PRISM scores at the beginning, in the middle, and at the end of critical illness we will test the hypothesis that arginine levels fall inversely with the severity of illness and rise as the patient improves.

这项研究将检验以下假设：危重儿科患者的血浆精氨酸水平通过测量血浆精氨酸水平与Prism III（死亡率的儿科风险）得分同时测量血浆精氨酸水平来影响其疾病的严重程度。 通过测量一开始，中间的精氨酸水平和棱镜得分之间的相关性，我们将检验以下假设：精氨酸水平随着疾病的严重程度而增长并随着患者的改善而呈上升。