UTIL OF HIGHLY SENS TSH-IRMA ASSAY FOR MONITORING SUPPRESSION OF PIT/AXIS

利用高灵敏度 TSH-IRMA 检测来监测凹陷/轴的抑制

• 批准号: 6297938
• 负责人: DOUGLAS S ROSS
• 金额: $ 0.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297938
• 关键词: bone density; clinical research; clinical trial phase I; dosage; drug adverse effect; drug screening /evaluation; endocrine disorder chemotherapy; endocrine pharmacology; female; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; pituitary thyroid axis; thyroid disorder; thyroxine

This is a randomized prospective study to compare the efficacy of fully suppressive vs partially suppressive doses of 1-thyroxine in shrinking abnormal thyroid tissue, and to evaluate changes in bone density which may occur in patients taking suppressive doses of 1-thyroxine, and to determine if any documented adverse effects of 1-thyroxine on peripheral organs can be minimized by using partially suppressive, rather than fully suppressive doses of 1-thyroxine.

这是一项随机前瞻性研究，目的是比较Fully 1-甲状腺素收缩抑制剂量与部分抑制剂量的比较 异常的甲状腺组织，并评估骨密度的变化 可能发生在服用抑制剂量的1-甲状腺素的患者，以及 确定1-甲状腺素对外周血是否有任何已记录的不良反应 可以使用部分抑制来最小化器官，而不是 完全抑制剂量的1-甲状腺素。