UTIL OF HIGHLY SENS TSH-IRMA ASSAY FOR MONITORING SUPPRESSION OF PIT/AXIS

这是一项随机前瞻性研究，目的是比较完全抑制剂量的1-甲状腺素与部分抑制剂量的1-甲状腺素缩小异常甲状腺组织的疗效，评估服用抑制剂量的1-甲状腺素患者可能发生的骨密度变化，并确定是否可以通过使用部分抑制剂量的1-甲状腺素而不是完全抑制剂量的1-甲状腺素来最大限度地减少已记录的对周围器官的不良影响。MGH研究人员之前的数据表明，抑制剂量的甲状腺素可能与骨质疏松症有关。一种高度敏感的(第三代)检测方法可以区分部分抑制性和完全抑制性甲状腺激素剂量。目前没有足够的数据来报告任何结论。最终数据分析将在所有患者入选并进行前瞻性跟踪后进行。调查人员计划继续收集所有登记患者的数据。

This is a randomized prospective study to compare the efficacy of fully suppressive vs partially suppressive doses of 1-thyroxine in shrinking abnormal thyroid tissue, and to evaluate changes in bone density which may occur in patients taking suppressive doses of 1-thyroxine, and to determine if any documented adverse effects of 1-thyroxine on peripheral organs can be minimized by using partially suppressive, rather than fully suppressive doses of 1-thyroxine. Previous data by MGH investigators have suggested that "suppressive" doses of thyroxine may be asociated with osteoporosis. A highly sensitive (3rd generation) assay allows discrimination between partially and fully suppressive thyroxine doses. There are insufficient data to report any conclusions at the present time. Final data analysis will occur after all patients have been enrolled and prospectively followed. The investigators plan to continue to accrue data for all enrolled patients.