ROLE OF OVARIAN HORMONES AND PARATHYROID HORMONE IN BONE METABOLISM

本研究的目的是确定1)PTH是否可以预防女性性腺功能减退引起的骨质流失，2)探讨卵巢激素对PTH和维生素D代谢的作用。本文将在年轻、成年女性和大鼠中研究卵巢激素和甲状旁腺激素（PTH）在骨代谢调节中的相互作用。首先，患有子宫内膜异位症的女性将接受长效ghrh类似物来诱导可逆性雌激素缺乏。这些患者中的一半还将每天接受甲状旁腺激素-(1-34)注射，以研究慢性甲状旁腺激素给药对维生素D代谢和骨量的影响，并确定甲状旁腺激素治疗是否可以预防性腺功能减退引起的骨质流失。其余的患者将作为对照，也将使用最先进的技术来确定性腺类固醇缺乏对甲状旁腺激素和维生素D代谢的影响。其次，年轻的绝经妇女在雌激素替代之前和期间接受静脉钙或PTH注射，以检查雌激素对阴道调节激素的影响。

The aims of this study are to determine 1) if PTH can prevent hypogonadism induced bone loss in women, 2) to investigate the roles of ovarian hormones on PTH and vitamin D metabolism. In this proposal the interactions of ovarian hormones and parathyroid hormone (PTH) in the regulation of bone metabolism will be investigated in young, adult women and rats. First, women will endometriosis will receive a long-acting GhRH-analogue to induce reversible estrogen deficiency. Half of these patients will also receive daily hPTH-(1-34) injections to investigate the effects of chronic PTH administration on vitamin D metabilism and bone mass and to determine whether PTH therapy can prevent hypogonadism-induced bone loss. The remaining patients will serve as controls and will also be used to define the effects of gonadal steroid deficiency on PTH and vitamin D metabolism using state-of-the-art techniques. Second, young menopausal women will receive IV calcium or PTH injections before and during estrogen replacement in order to examine the effects of estrogen on clcium regulitory hormones.