NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

描述(改编自申请人的摘要)：本提案旨在建立 神经机制生物医学研究卓越中心(Cobre) 美元的适应性行为。众所周知，人类和 动物受试者可以根据环境情况改变自己的行为。 对环境做出反应的行为改变是发生在大脑神经回路中的适应机制的外部表现。这个建议的主要目的是了解神经通路的结构重组是如何 导致对新的感觉-运动体验的适应性行为反应。 神经回路的功能重组是 发生在学习和记忆、发育和中枢神经系统中 系统对压力或伤害的反应。美元的神经科学小组已经 最近经历了显著的扩张，初级和初级员工的比例很高 高级教员，他们的主要智力目标将是 了解构成行为适应的大脑机制。 这个科布雷将有五个主要研究项目来解决这个问题 感觉运动适应。基弗博士将研究 体外经典条件反射。克里斯蒂博士和克拉克博士将检查 增强学习和记忆能力的分子机制 神经再生增加。科尔斯博士和施伦克博士将研究一种 呼吸模式生成器对缺氧做出反应。伦纳博士 萨默斯将研究类固醇和单胺对性、压力和性别的影响。 癫痫发作。最后，莫雷克拉夫特博士将评估焦点的潜在机制。 头颈肌张力障碍。Cobre的主要目标是为 理解形成适应行为和适应的细胞机制 开发一种全面的理论来解释发生在 具有自适应运动反应的细胞水平。解决这个问题的方法将是 是多学科的，运用生理学，药理学，解剖学， 分子和行为实验方法。

DESCRIPTION (Adapted from the applicant's abstract):This proposal is to establish a Center of Biomedical Research Excellence (COBRE) on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the USD. It is well-recognized that both human and animal subjects can modify their behavior in response to environmental situations. Behavioral modifications in response to the environment are an external manifestation of adaptive mechanisms that take place in neuronal circuits in the brain. The main aim of this proposed COBRE is to understand how structural reorganization in neural pathways results in adaptive behavioral responses to novel sensory-motor experiences. Functional reorganization of neural circuits is fundamental to processes that occur during learning and memory, development, and in the central nervous system's response to stress or injury. The Neuroscience Group at the USD has recently undergone significant expansion and has a strong mix of junior and senior faculty members whose main intellectual thrust will be aimed at understanding brain mechanisms that underlie behavioral adaptation. This COBRE will have five major research projects that address the problem of sensorimotor adaptation. Dr. Keifer will study synaptic mechanisms underlying in vitro classical conditioning. Drs. Christie and Clark will examine molecular mechanisms of enhanced learning and memory performance with increased neurogenesis. Drs. Coles and Schlenker will study adaptation of a respiratory pattern generator in response to oxygen deprivation. Drs. Renner and Summers will examine steroid and monamine effects on sex, stress and seizures. Finally, Dr. Morecraft will assess mechanisms underlying focal cranial-cervical dystonia. The main goal of COBRE is to contribute to an understanding of the cellular mechanisms that underlie adaptive behavior and to develop a comprehensive theory that accounts for changes occurring at the cellular level with adaptive motor responses. The approach to the problem will be multi-disciplinary, employing physiological, pharmacological, anatomical, molecular and behavioral experimental approaches.