NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

超出空间 提供了 这项建议是为了继续我们的生物医学研究卓越中心（COBRE）的神经 南达科他州大学的适应行为机制。人类和动物 受试者能够根据环境情况改变他们的行为。行为改变 是适应机制的外在表现， 大脑中的神经回路这种适应也发生在对内部线索的反应中，如压力和 可能产生焦虑和适应不良的行为反应，如可能在精神疾病中发生的。一个主要 我们的COBRE的研究目标是了解神经元的功能和结构重组是如何进行的。 通路导致适应性，或在某些情况下适应不良，对外部或感知的行为反应。 经验此外，我们的COBRE在拟议资助期内的主要目标是， 通过我们的基础研究优势，在我们的机构发展临床神经科学研究 科学家为了实现这一目标，我们的COBRE提出的五个新的研究项目将研究细胞 在学习和大脑疾病（如精神分裂症、焦虑和成瘾）过程中发生的变化，以及 将提供一个桥梁，建立一个基础，合作面向病人的研究之间的基础， 科学家和临床医生。美国南达科他州大学神经科学研究小组和 南达科他州医学院（USDSM）在基础科学方面经历了重大扩张， 过去几年，主要是由于我们的COBRE的资金。随着资金的持续投入，我们建议扩大 神经科学基础和临床研究在一个地区，北方中西部，这是传统上高度 在精神卫生保健方面服务不足，基础和临床研究资金不足， 加强与改善创伤后或疾病状态下的脑功能障碍相关的治疗。

EXCEED THE SPACE PROVIDED. This proposal is for continuation of our Center of Biomedical Research Excellence (COBRE) on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the University of South Dakota. Both human and animal subjects are able to modify their behavior in response to environmental situations. Behavioral modifications in response to the environment are an external manifestation of adaptive mechanisms that take place in neuronal circuits in the brain. Such adaptations also occur in response to internal cues such as stress and anxiety and maladaptive behavioral responses may be generated as may occur in mental illness. A major research goal of our COBRE is to understand how functional and structural reorganization of neuronal pathways results in adaptive, or in some cases maladaptive, behavioral responses to external or perceived experiences. Moreover, a primary objective of our COBRE in the proposed funding period is to significantly develop clinical neuroscience research at our institution through the research strengths of our basic scientists. To achieve this aim, the five new research projects proposed by our COBRE will examine cellular changes that occur during learning and brain disorders such as schizophrenia, anxiety and addiction, and will provide a bridge toward establishing a base for collaborative patient-oriented research among basic scientists and clinicians. The Neuroscience Group at the University of South Dakota (USD) and University of South Dakota School of Medicine (USDSM) has undergone significant expansion in the basic sciences in the last several years due largely by the funding of our COBRE. With continued funding, we propose to expand neuroscience basic and clinical research in a region, the northern midwest, that is traditionally highly underserved in terms of mental health care and underfunded for both basic and clinical research directed at enhancing treatments related to improving brain dysfunctionfollowing trauma or in disease states.