USD MED: NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。南达科他大学的适应行为神经机制中心的组织是为了了解神经系统如何使行为适应环境的变化。我们中心的主要目的是研究神经通路的结构重组，这些通路导致对新的感觉-运动体验的适应性行为反应。神经回路的功能重组是发生在学习和记忆、发育、中枢神经系统对压力的反应以及疾病状态(如中枢神经系统损伤后和精神疾病)过程中的基本过程。我们的Cobre有四个主要的研究项目来解决感觉运动适应的问题。乔伊斯·基弗博士研究了经典条件作用下的突触机制。Evelyn Schlenker博士对呼吸模式发生器在缺氧时的适应性很感兴趣。肯·伦纳博士和克里夫·萨默斯博士研究了类固醇和单胺类药物对性、压力和癫痫的影响。最后，Bob Morecraft博士评估了局灶性颅颈肌张力障碍的潜在机制。此外，该中心的主要项目还增加了另外八名研究人员。其中包括蒂莫西·克拉克博士，他研究海马体的可塑性机制。Josette Lindahl博士在一个大鼠模型中研究精神分裂症的谷氨酸受体机制。布莱恩·伯瑞尔博士，研究无脊椎动物联想学习的细胞机制。研究RNAi在压力调节中的作用的Pat Ronan博士。艾丽西亚·保尔森博士，研究胚胎发育中细胞与细胞的相互作用。福斯特和瓦特博士，他们研究压力的神经化学效应及其与成瘾和焦虑症的关系。曼泽拉博士研究突触后密度中的突触信号。总而言之，这些项目的主要目标是帮助理解构成适应性行为基础的细胞机制，并开发一种全面的理论，解释适应性运动反应过程中细胞水平发生的变化。该中心允许美国大学的研究人员获得新的设备，如激光扫描共聚焦显微镜，以促进教师发展，最重要的是，通过增加新的教师来建立神经科学的基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the University of South Dakota is organized to understand how the nervous system adapts behavior to changes in the environment. The main aim of our Center is to study the structural reorganization of neural pathways that results in adaptive behavioral responses to novel sensory-motor experiences. Functional reorganization of neural circuits is fundamental to processes that occur during learning and memory, development, and in the central nervous system's response to stress, and during disease states such as occurs following injury to the CNS and in mental illness. Our COBRE has four primary research projects that address the problem of sensorimotor adaptation. Dr. Joyce Keifer studies synaptic mechanisms underlying in vitro classical conditioning. Dr. Evelyn Schlenker is interested in adaptation of a respiratory pattern generator in response to oxygen deprivation. Drs. Ken Renner and Cliff Summers examine steroid and monoamine effects on sex, stress and seizures. Finally, Dr. Bob Morecraft assesses mechanisms underlying focal cranial-cervical dystonia. Additionally, eight other researchers have been added to the primary projects of the Center. These include Dr. Timothy Clark who studies mechanisms of plasticity in the hippocampus. Dr. Josette Lindahl who studies glutamate receptor mechanisms underlying schizophrenia in a rat model. Dr. Brian Burrell who studies cellular mechanisms of associative learning in invertebrates. Dr. Pat Ronan who examines the role of RNAi in stress regulation. Dr. Alicia Paulson who studies cell-cell interactions in embryonic development. Drs. Forster and Watt who study the neurochemical effects of stress and their relation to addiction and anxiety disorders. And, Dr. Manzerra who studies synaptic signalling in the postsynaptic density. Together, the main goal of these projects is to contribute to an understanding of the cellular mechanisms that underlie adaptive behavior and to develop a comprehensive theory that accounts for changes occurring at the cellular level during adaptive motor responses. The Center allows USD researchers to acquire new equipment such as a laser scanning confocal microscope, to enhance faculty development, and most importantly, to build infrastructure in neuroscience by the addition of new faculty members.