USD MED: NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。南达科他州大学适应行为的神经机制中心旨在了解神经系统如何使行为适应环境的变化。我们中心的主要目的是研究神经通路的结构重组，从而导致对新的感觉运动体验的适应性行为反应。神经回路的功能重组对于学习和记忆、发育、中枢神经系统对压力的反应、疾病状态（如中枢神经系统损伤和精神疾病）中发生的过程至关重要。我们的COBRE有四个主要的研究项目来解决感觉运动适应的问题。Joyce Keifer博士研究体外经典条件反射的突触机制。伊芙琳·施伦克博士对适应缺氧的呼吸模式发生器很感兴趣。Drs。肯·雷纳和克利夫·萨默斯研究了类固醇和单胺对性、压力和癫痫的影响。最后，Bob Morecraft博士评估局灶性颅颈肌张力障碍的机制。此外，中心的主要项目还增加了8名研究人员。其中包括研究海马体可塑性机制的蒂莫西·克拉克博士。Josette Lindahl博士在大鼠模型中研究谷氨酸受体机制导致精神分裂症。布莱恩·伯勒尔博士研究无脊椎动物联想学习的细胞机制。帕特·罗南博士研究了RNAi在压力调节中的作用。艾丽西亚·保尔森博士研究胚胎发育中的细胞-细胞相互作用。Drs。福斯特和瓦特，他们研究压力的神经化学效应及其与成瘾和焦虑症的关系。Manzerra博士研究突触后密度中的突触信号。总之，这些项目的主要目标是有助于理解适应行为背后的细胞机制，并发展一个全面的理论，解释适应性运动反应期间细胞水平上发生的变化。该中心允许美国研究人员获得新的设备，如激光扫描共聚焦显微镜，以加强师资队伍的发展，最重要的是，通过增加新的师资队伍来建立神经科学的基础设施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Center on NEURAL MECHANISMS OF ADAPTIVE BEHAVIOR at the University of South Dakota is organized to understand how the nervous system adapts behavior to changes in the environment. The main aim of our Center is to study the structural reorganization of neural pathways that results in adaptive behavioral responses to novel sensory-motor experiences. Functional reorganization of neural circuits is fundamental to processes that occur during learning and memory, development, and in the central nervous system's response to stress, and during disease states such as occurs following injury to the CNS and in mental illness. Our COBRE has four primary research projects that address the problem of sensorimotor adaptation. Dr. Joyce Keifer studies synaptic mechanisms underlying in vitro classical conditioning. Dr. Evelyn Schlenker is interested in adaptation of a respiratory pattern generator in response to oxygen deprivation. Drs. Ken Renner and Cliff Summers examine steroid and monoamine effects on sex, stress and seizures. Finally, Dr. Bob Morecraft assesses mechanisms underlying focal cranial-cervical dystonia. Additionally, eight other researchers have been added to the primary projects of the Center. These include Dr. Timothy Clark who studies mechanisms of plasticity in the hippocampus. Dr. Josette Lindahl who studies glutamate receptor mechanisms underlying schizophrenia in a rat model. Dr. Brian Burrell who studies cellular mechanisms of associative learning in invertebrates. Dr. Pat Ronan who examines the role of RNAi in stress regulation. Dr. Alicia Paulson who studies cell-cell interactions in embryonic development. Drs. Forster and Watt who study the neurochemical effects of stress and their relation to addiction and anxiety disorders. And, Dr. Manzerra who studies synaptic signalling in the postsynaptic density. Together, the main goal of these projects is to contribute to an understanding of the cellular mechanisms that underlie adaptive behavior and to develop a comprehensive theory that accounts for changes occurring at the cellular level during adaptive motor responses. The Center allows USD researchers to acquire new equipment such as a laser scanning confocal microscope, to enhance faculty development, and most importantly, to build infrastructure in neuroscience by the addition of new faculty members.