Disrupting mucin-mucin interactions to treat respiratory diseases

破坏粘蛋白-粘蛋白相互作用来治疗呼吸道疾病

• 批准号: nhmrc : 1139549
• 负责人: Dr Rhys Allan
• 金额: $ 32.49万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/disrupting-mucin-mucin-respiratory-diseases/1319011
• 关键词: Disrupting; mucin; interactions; treat; respiratory

Diseases like asthma, emphysema and cystic fibrosis all feature the overproduction of mucus in the lungs that make it very difficult for patients to breathe and increases their susceptibility to infections. Few therapies are available for thinning this mucus, which is made thick by a network of linkages between proteins. We are studying these linkages and developing methods to break them up. This research could yield new mucus-thinning drugs to treat lung diseases.

哮喘、肺气肿和囊性纤维化等疾病的特点都是肺部粘液分泌过多，使患者呼吸困难，增加了感染的易感性。很少有治疗方法可以使这种粘液变薄，这种粘液是由蛋白质之间的连接网络变厚的。我们正在研究这些联系，并制定打破这些联系的方法。这项研究可能会产生新的粘液稀释药物来治疗肺部疾病。