Deciphering the epigenetic code of T lymphocyte stability in disease

破译疾病中 T 淋巴细胞稳定性的表观遗传密码

• 批准号: nhmrc : 1049307
• 负责人: Dr Rhys Allan
• 金额: $ 44.19万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deciphering-epigenetic-code-stability-disease/112074
• 关键词: Deciphering; epigenetic; code; lymphocyte; stability

T lymphocytes defend against invading pathogens and establish immunological memory to protect us if the infection returns. As there are many different types of pathogens, T lymphocytes must be flexible in the way they respond to infection but also stable once they have decided on the appropriate type of response. This complex decision-making appears to be dictated by epigenetic changes to the chromatin state of the cell. This work will uncover epigenetic factors that maintain this balance to protect us against disease.

T淋巴细胞防御入侵的病原体，并建立免疫记忆，以保护我们，如果感染复发。由于有许多不同类型的病原体，T淋巴细胞对感染的反应方式必须是灵活的，但一旦它们决定了适当的反应类型，它们也必须是稳定的。这种复杂的决策似乎是由细胞染色质状态的表观遗传变化决定的。这项工作将揭示维持这种平衡以保护我们免受疾病侵害的表观遗传因素。