ROLE OF UV INDUCED CYTOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF PTERYGIUM

紫外线诱导的细胞因子和生长因子在翼状胬肉发病机制中的作用

• 批准号: 6268411
• 负责人: JOHN C ANSEL
• 金额: $ 6.18万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6268411
• 关键词: angiogenesis; conjunctiva; cornea disorder; cytokine; growth factor; human tissue; hypertrophy; immunologic assay /test; light adverse effect; tissue /cell culture; ultraviolet radiation

Chronic UV exposure to the eye has been linked to the development of pterygium. However, the pathogenesis of this effect is unclear. We propose that UV may trigger this vascular hyperproliferative lesion by the induction of conjunctival and corneal cytokines and growth factors that result in overgrowth of the conjunctiva into the cornea. Specific Aims: 1: To determine the effect of UV on specific corneal and conjunctival epithelial cell cytokines and growth factors. 2: To examine the production of specific cytokines and growth factors in human pterygium tissue.

眼睛长期接触紫外线与眼睛的发展有关 翼状胬肉。然而，这种效应的发病机制尚不清楚。我们 提出紫外线可能通过以下方式引发这种血管过度增殖性病变 诱导结膜和角膜细胞因子和生长因子 这导致结膜过度生长到角膜中。 具体目标： 1：确定紫外线对特定角膜和结膜的影响 上皮细胞细胞因子和生长因子。 2：检查特定细胞因子和生长因子的产生 在人类翼状胬肉组织中。