ROLE OF UV INDUCED CYTOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF PTERYGIUM

长期暴露在紫外线下的眼睛与以下疾病的发展有关： 翼状胬肉然而，这种效应的发病机制尚不清楚。我们 提出紫外线可能通过以下方式引发这种血管过度增生性病变： 结膜和角膜细胞因子和生长因子的诱导 导致结膜过度生长到角膜中。 具体目标： 1：确定紫外线对特定角膜和结膜的影响 上皮细胞细胞因子和生长因子。 2：检查特定细胞因子和生长因子的产生 在人类翼状胬肉组织中。

Chronic UV exposure to the eye has been linked to the development of pterygium. However, the pathogenesis of this effect is unclear. We propose that UV may trigger this vascular hyperproliferative lesion by the induction of conjunctival and corneal cytokines and growth factors that result in overgrowth of the conjunctiva into the cornea. Specific Aims: 1: To determine the effect of UV on specific corneal and conjunctival epithelial cell cytokines and growth factors. 2: To examine the production of specific cytokines and growth factors in human pterygium tissue.