Determining the mechanisms of transgenerational epigenetic inheritance.

确定跨代表观遗传的机制。

• 批准号: DE140100199
• 负责人: A/Prof Alyson Ashe
• 金额: $ 29.33万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-06 至 2018-03-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140100199
• 关键词: Determining; mechanisms; transgenerational; epigenetic; inheritance.

Although previously controversial, there is now little doubt that transgenerational inheritance of epigenetic marks can occur. This phenomenon is difficult to study in humans and many model organisms, in part due to long generation times. To avoid this difficulty, this project will use genetic and molecular biology approaches in the model organism Caenorhabditis. elegans. The project will utilise a robust assay for transgenerational epigenetic inheritance established to identify a collection of genes involved in the process and will determine the interplay between chromatin modifications and small RNA molecules. This project aims to determine the exact epigenetic mark that is transmitted and the mechanisms by which the transmission occurs.

尽管之前存在争议，但现在几乎毫无疑问的是，表观遗传标记可以发生跨代遗传。这种现象很难在人类和许多模式生物中进行研究，部分原因是世代时间很长。为了避免这一困难，该项目将在模式生物线虫中使用遗传和分子生物学方法。优雅女装。该项目将使用一种强大的跨代表观遗传分析方法，以确定参与这一过程的基因集合，并将确定染色质修饰和小RNA分子之间的相互作用。该项目旨在确定传播的确切表观遗传标记以及传播发生的机制。