How is molecular information passed between generations?

分子信息如何在代际间传递？

• 批准号: DP200102904
• 负责人: A/Prof Alyson Ashe
• 金额: $ 45.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102904
• 关键词: How; molecular; information; passed; between

This project aims to determine the mechanisms responsible for the inheritance of acquired traits. Sometimes the environment can have effects on the phenotype of not only the exposed individual, but also their children and grandchildren. While it is clear that this can occur, what is not clear is the mechanism by which this happens and the frequency at which it happens. This project will combine use of the model organism Caenorhabditis elegans with biochemistry and structural biology to determine what the molecular mechanism is by which this "transgenerational epigenetic inheritance" occurs.

这个项目的目的是确定机制负责遗传后天性状。有时，环境不仅会影响受照射者的表型，还会影响其子女和孙辈。虽然很明显，这种情况可能会发生，但不清楚的是这种情况发生的机制和发生的频率。该项目将联合收割机使用模式生物秀丽隐杆线虫与生物化学和结构生物学，以确定这种“跨代表观遗传”发生的分子机制是什么。