Discovering the molecular controls of epigenetic inheritance

发现表观遗传的分子控制

• 批准号: DP240100725
• 负责人: A/Prof Alyson Ashe
• 金额: $ 48.73万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100725
• 关键词: Discovering; molecular; controls; epigenetic; inheritance

This project aims to investigate the way in which acquired traits can be inherited. The environment that an individual is exposed to can change the characteristics of not only that individual, but also their children and grandchildren. We do not yet understand the mechanisms by which this “epigenetic inheritance” occurs. Using interdisciplinary approaches, this project combines the power of the model organism Caenorhabditis elegans with cutting-edge single molecule microscopy techniques to determine the molecular mechanisms by which the environment can impact future generations. This should ultimately provide society with the means to harness the power of epigenetics.

这个项目旨在研究后天获得的特征可以遗传的方式。一个人所处的环境不仅会改变这个人的特征，还会改变他们的子孙后代的特征。我们还不了解这种“表观遗传”发生的机制。利用跨学科的方法，该项目结合了模式生物秀丽隐杆线虫的力量与尖端的单分子显微镜技术，以确定环境影响后代的分子机制。这最终将为社会提供利用表观遗传学力量的手段。