Dissecting the function of heparanase in inflammatory disease using genetic tissue-specific ablation

使用遗传组织特异性消融剖析乙酰肝素酶在炎症性疾病中的功能

• 批准号: nhmrc : 471424
• 负责人: Dr Mark Hulett
• 金额: $ 38.73万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-function-heparanase-specific-ablation/96638
• 关键词: Dissecting; function; heparanase; inflammatory; disease

This project aims to define the role of the enzyme heparanase in a number of important diseases, namely Inflammatory-autoimmune diseases such as multiple scelorosis and rheumatiod arthritis, and the growth and spread of cancer. Heparanase has been implicated for many years in promoting these diseases however its precise contribution has not beed defined. These studies will provide definitive information whether heparanase is a valid therapuetic target in these important disease settings.

该项目旨在确定乙酰肝素酶在许多重要疾病中的作用，即炎症-自身免疫性疾病，如多发性硬化症和类风湿性关节炎，以及癌症的生长和扩散。乙酰肝素酶多年来一直被认为与这些疾病有关，但其确切作用尚未明确。这些研究将提供明确的信息，乙酰肝素酶是否是一个有效的治疗目标，在这些重要的疾病设置。