The function of histidine-rich glycoprotein in inflammation and cancer

富含组氨酸的糖蛋白在炎症和癌症中的功能

• 批准号: nhmrc : 418008
• 负责人: Dr Mark Hulett
• 金额: $ 30.38万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/function-histidine-rich-inflammation-cancer/76358
• 关键词: function; histidine; rich; glycoprotein; inflammation

This research proposal investiagtes the role of a molecule known as histidine-rich glycoprotein (HRG) in the important diseases of cancer and inflammation. Inflammatory diseases can occur when the the normal checks on the immune system breakdown resulting in attacks on the body leading to tissue damage (e.g rheumatoid arthritis) and are significant contributors to morbidity and health costs in Australia. Cancer is the leading cause of death in Australia (28.4% of deaths in 2003). HRG has been implicated in controlling important aspects of inflammatory and cancer disease progression. Namely, HRG appears to regulate the formation and clearance of substances known as immune complexes - the primary cause of tissue damage in this disease. Furthermore, HRG may also control the process of cell invasion which is crucial for the migration of white blood cells of the immune system (leukocytes) to sites of inflammation to combat infections, and is also an important mechanism by which malignant tumour cells escape from primary tumour sites and spread throughout the circulation to other sites in the body. It is this process that makes cancer such a deadly disease. This study aims to define how HRG contributes to these important processes. This information may allow the development of new therapeutic approaches for the treatment of inflammatory diseases and cancer.

这项研究计划调查了一种被称为富含组氨酸的糖蛋白（HRG）的分子在癌症和炎症等重要疾病中的作用。当免疫系统的正常检查失败时，炎症性疾病可能会发生，从而导致对身体的攻击，导致组织损伤（例如类风湿性关节炎），并且是澳大利亚发病率和健康成本的重要贡献者。癌症是澳大利亚的主要死因（2003年占死亡人数的28.4%）。HRG与控制炎症和癌症疾病进展的重要方面有关。也就是说，HRG似乎可以调节称为免疫复合物的物质的形成和清除--免疫复合物是这种疾病组织损伤的主要原因。此外，HRG还可以控制细胞侵入的过程，这对于免疫系统的白色血细胞（白细胞）迁移到炎症部位以对抗感染是至关重要的，并且也是恶性肿瘤细胞从原发性肿瘤部位逃逸并通过循环扩散到体内其他部位的重要机制。正是这个过程使癌症成为一种致命的疾病。本研究旨在确定HRG如何有助于这些重要的过程。这一信息可能允许开发用于治疗炎性疾病和癌症的新治疗方法。