Dissecting human B-cell function: from primary immunodeficiencies to chronic inflammatory disease

剖析人类 B 细胞功能：从原发性免疫缺陷到慢性炎症性疾病

• 批准号: nhmrc : GNT1117687
• 负责人: A/Pr Menno van Zelm
• 金额: $ 63.14万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-human-b-inflammatory-disease/1347046
• 关键词: Dissecting; human; cell; function; primary

Despite knowing a lot about immunity in a mice, functional analysis of the human immune system has been a major challenge. I will study defects of immune cells in humans with gene mutations that cause an antibody deficiency. With new insights from these unique clinical samples, I will functionally dissect human immune responses, directly translate these to chronic inflammatory disease, and provide implications for future vaccine development and cancer treatment.

尽管对小鼠的免疫了解很多，但人类免疫系统的功能分析一直是一个重大挑战。我将研究人类免疫细胞的缺陷，其基因突变会导致抗体缺陷。凭借从这些独特的临床样本中获得的新见解，我将从功能上剖析人类免疫反应，将其直接转化为慢性炎症性疾病，并为未来的疫苗开发和癌症治疗提供启示。