MATERNAL SERUM INTERLEUKIN 6 IN PRETERM PREMATURE RUPTURE OF MEMBRANES

早产儿胎膜早破中的母体血清白细胞介素 6

• 批准号: 6274019
• 负责人: AMY P. MURTHA
• 金额: $ 2.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274019
• 关键词: blood chemistry; clinical research; female; histology; human subject; interleukin 6; pregnancy infection; serology /serodiagnosis

Background: Preterm premature rupture of membranes (PROM) continues to be a leading cause of neonatal morbidity and mortality. Preterm PROM occurs in approximately 2% of all pregnancies but is associated with 20% of all perinatal deaths. By far, the most common complication of preterm PROM is related to intra-amniotic infection termed chorioamnionitis. Chorioamnionitis occurs in 6% of preterm deliveries without PROM but is present in at least 27% of preterm deliveries with PROM; it is associated with a fourfold increase in neonatal mortality. Clinical signs of infection are subtle and usually not present in early chorioamnionitis. Currently there are no reliable clinical markers to adequately indicate impending intrauterine infection in these patients. The cytokine interleukin(IL)-6, thought to have an important role in the intrauterine response to infection, has been reported to be elevated in the amniotic fluid of patients with preterm PROM with intra-amniotic infection. Unfortunately, the widespread clinical use of amniotic fluid IL-6 concentrations in the management of preterm PROM patients would be limited due to the technical difficulty of amniocentesis. Recent studies in our laboratory demonstrate a significant rise in serum IL-6 concentrations in patients with preterm PROM and clinical or histologic evidence of infection on the day of delivery.

背景：早产胎膜早破（PROM）仍然是 是新生儿发病率和死亡率的主要原因。 早产PROM发生 大约2%的怀孕，但与20%的 围产期死亡 到目前为止，早产胎膜早破最常见的并发症是 与羊膜内感染绒毛膜炎有关 绒毛膜炎发生在6%的早产无胎膜早破， 至少有27%的胎膜早破早产;它与 新生儿死亡率增加了四倍 的临床体征 感染是轻微且通常不存在于早期绒毛膜炎中。 目前没有可靠的临床标志物来充分指示 这些患者的子宫内感染。 细胞因子白细胞介素（IL）-6，被认为具有重要的作用， 子宫内对感染的反应，据报道在 羊水内注射治疗早产胎膜早破 感染不幸的是，羊水的广泛临床应用 IL-6浓度在早产胎膜早破患者的管理将是 由于穿刺术的技术难度而受到限制。 最近的研究 在我们实验室中证实血清IL-6显著升高 早产胎膜早破患者和临床或组织学 分娩当天有感染的迹象。