Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases
Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases
批准号:
nhmrc : 1143638
负责人:
Dr Begona Heras
金额:
$43.23万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
SPATEs are proteases secreted by many enteric bacteria that contribute to their pathogenic potential by damaging host tissues and evading the host immune response. We aim to study the structural basis of their assembly and biological function. The information we gain will assist the development of new diagnostics and improved therapies for enteric infections.
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Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases
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批准号:nhmrc : GNT1143638
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项目类别:Project Grants
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资助金额:$63.94万
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财政年份:2018
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负责人:Dr Begona Heras
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依托单位:
DsbA foldases from multidrug resistant pathogens as targets for new antimicrobials
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DsbA inhibitors: from hits to leads
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项目类别:Project Grants
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负责人:Dr Begona Heras
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依托单位:
Structure-based design of inhibitors of oxidative protein folding in Enterobacteriaceae.
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DsbA inhibitors as potential antimicrobials
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负责人:Dr Begona Heras
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