课题基金 / 基金详情

Structure-based design of inhibitors of oxidative protein folding in Enterobacteriaceae.

Structure-based design of inhibitors of oxidative protein folding in Enterobacteriaceae.
肠杆菌科氧化蛋白折叠抑制剂的基于结构的设计。
批准号:
nhmrc : 1009785
负责人:
Dr Begona Heras
金额:
$34.91万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

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中文摘要
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英文摘要
Antibiotic resistance represents a major public health problem. For gram-negative bacteria in particular, the situation is increasingly bleak, with the accumulation of resistance to existing drugs and few if any new drugs in the pipeline. We are using structure-based drug design to develop novel strategies for the treatment of gram-negative bacterial infections.
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会议论文
Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases
  • 批准号:
    nhmrc : 1143638
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.23万
  • 财政年份:
    2018
  • 负责人:
    Dr Begona Heras
  • 依托单位:
Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases
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    nhmrc : GNT1143638
  • 项目类别:
    Project Grants
  • 资助金额:
    $63.94万
  • 财政年份:
    2018
  • 负责人:
    Dr Begona Heras
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DsbA foldases from multidrug resistant pathogens as targets for new antimicrobials
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    nhmrc : 1144046
  • 项目类别:
    Project Grants
  • 资助金额:
    $50.26万
  • 财政年份:
    2018
  • 负责人:
    Dr Begona Heras
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DsbA inhibitors: from hits to leads
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    nhmrc : 1099151
  • 项目类别:
    Project Grants
  • 资助金额:
    $60.54万
  • 财政年份:
    2016
  • 负责人:
    Dr Begona Heras
  • 依托单位:
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Exploring the Intrinsic Mechanisms of CEO Turnover and Market Reaction: An Explanation Based on Information Asymmetry
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    W2433169
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含Re、Ru先进镍基单晶高温合金中TCP相成核—生长机理的原位动态研究
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  • 批准年份:
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