Biocontainment Core

生物围堵堆芯项目总结 夏威夷作为著名国际港口的地理位置和毗邻亚洲的战略位置使其成为 自然哨所，用于监测新发现的传染性疾病的出现和传播 并调查亚太地区众所周知的微生物感染的暴发。在.期间 最初的第一阶段科布雷时期，建立了一个多学科中心来调查新出现的传染病 影响夏威夷多民族人口的疾病。当时，一架最先进的ABSL-3/BSL-3 位于国家资助的生物科学大楼的生物遏制设施是作为一个 生物控制核心。作为全州研究人员唯一的同类设施，生物遏制 核心代表着一项宝贵的地方和区域资产。对于科布雷第二阶段，基础设施 生物遏制核心得到增强，以支持寻求开发的假说驱动的研究项目 针对新出现的传染病的快速诊断、改进的治疗和负担得起的疫苗。导演： 作为一名高级病毒学家，在训练有素的工作人员的帮助下，生物遏制核心提供了 在BSL-2和BSL-3生物遏制下研究致病微生物的机会；此外，核心具有 为用户提供培训讲习班并协助认证和许可过程。 在Cobre第一阶段和第二阶段，生物遏制核心专注于服务、研究和 发展，以及教育和培训。这些核心职能将延伸到第三阶段，以支持职业生涯 UH系统内外教职员工发展和研究的独立性。此外，一个高度优先的 在科布雷期间，第三阶段是确保生物遏制核心的可持续性和增长。因此， 总体目标是促进将生物遏制核心转变为可持续的最先进技术 能够支持对新的、新兴的和重新出现的传染病进行高水平研究的核心设施 疾病。目标将通过以下方式实现：(1)加强和精简核心业务；(2)发展和 使用户基础、能力、能力和覆盖范围多样化；以及(3)加强核心基础设施。 预计生物遏制核心将在#年底实现上述每一项具体目标。 第三阶段的眼镜蛇。此外，高级别机构官员的坚定承诺将确保 核心业务将在第三阶段科布雷期间及之后持续下去。

Project Summary for the Biocontainment Core Hawaii's geographic location as a prominent international port and its strategic proximity to Asia makes it a natural sentinel post from which to monitor the emergence and spread of newly recognized infectious diseases and to investigate outbreaks of well-known microbial infections in the Asia-Pacific region. During the initial Phase I COBRE period, a multidisciplinary center was established to investigate emerging infectious diseases that impact Hawaii's multiethnic population. At that time, a state-of-the-art ABSL-3/BSL-3 biocontainment facility, located in the State-financed BioSciences Building, was developed as a Biocontainment Core. As the only facility of its kind for researchers in the entire State, the Biocontainment Core represents a valuable local and regional asset. For the Phase II COBRE period, the infrastructure for the Biocontainment Core was enhanced to support hypothesis-driven research projects that sought to develop rapid diagnostics, improved treatments and affordable vaccines for emerging infectious diseases. Directed by a senior virologist with assistance from a well-trained staff, the Biocontainment Core has provided opportunities for studying pathogenic microbes under BSL-2 and BSL-3 biocontainment; also, the Core has provided training workshops and assisted in the certification and permitting process for users. During COBRE Phases I and II, the Biocontainment Core focused on the triad of service, research and development, and education and training. These core functions will extend into Phase III to support the career development and research independence of faculty within the UH System and beyond. Further, a high priority during COBRE Phase III is to ensure the sustainability and growth of the Biocontainment Core. Thus, the overarching objective is to facilitate the transition of the Biocontainment Core into a sustainable state-of-the-art core facility capable of supporting high-caliber research on new, emerging and re-emerging infectious diseases. The objective will be achieved by (1) enhancing and streamlining core operations; (2) growing and diversifying the user base, capability, capacity and reach; and (3) strengthening the core infrastructure. It is envisioned that the Biocontainment Core will achieve each of the above-stated specific aims by the end of the Phase III COBRE. Moreover, the strong commitments by high-level institutional officials will ensure that core operations will be sustained during and beyond the Phase III COBRE period.