Biocontainment Core

生物防护核心项目摘要 夏威夷作为一个重要的国际港口的地理位置和它靠近亚洲的战略位置使它成为一个 天然哨站，从那里监测新发现的传染病的出现和传播。 疾病和调查亚太区域众所周知的微生物感染的爆发。期间 在第一阶段COBRE期间，建立了一个多学科中心，以调查新出现的传染病 影响夏威夷多民族人口的疾病。当时，最先进的ABSL-3/BSL-3 位于国家资助的生物科学大楼内的生物遏制设施是作为一个 生物防护核心作为整个国家唯一的研究人员设施，生物遏制 核心代表了宝贵的本地和区域资产。在COBRE第二阶段期间， 加强了生物遏制核心，以支持假设驱动的研究项目， 快速诊断、改进的治疗和负担得起的新传染病疫苗。导演 在训练有素的工作人员的协助下，生物遏制核心提供了 在BSL-2和BSL-3生物防护下研究病原微生物的机会;此外，核心 提供培训讲习班，并协助用户的认证和许可程序。 在COBRE第一和第二阶段，生物防护核心集中在服务、研究和 发展、教育和培训。这些核心职能将延伸到第三阶段， 在UH系统内外的教师的发展和研究的独立性。此外，高度优先 COBRE第三阶段的主要任务是确保生物防护核心的可持续性和增长。因此 总体目标是促进生物防护核心区向可持续发展的最先进技术的过渡 核心设施，能够支持新的，新兴的和重新出现的传染病的高水平研究 疾病将通过以下方式实现这一目标：（1）加强和精简核心业务;（2）扩大和 使用户基础、能力、容量和覆盖面多样化;以及（3）加强核心基础设施。 据设想，生物防护核心将在2008年底前实现上述各项具体目标。 第三阶段COBRE。此外，高级别机构官员的坚定承诺将确保， 在COBRE第三阶段期间和之后，将维持核心业务。

Project Summary for the Biocontainment Core Hawaii's geographic location as a prominent international port and its strategic proximity to Asia makes it a natural sentinel post from which to monitor the emergence and spread of newly recognized infectious diseases and to investigate outbreaks of well-known microbial infections in the Asia-Pacific region. During the initial Phase I COBRE period, a multidisciplinary center was established to investigate emerging infectious diseases that impact Hawaii's multiethnic population. At that time, a state-of-the-art ABSL-3/BSL-3 biocontainment facility, located in the State-financed BioSciences Building, was developed as a Biocontainment Core. As the only facility of its kind for researchers in the entire State, the Biocontainment Core represents a valuable local and regional asset. For the Phase II COBRE period, the infrastructure for the Biocontainment Core was enhanced to support hypothesis-driven research projects that sought to develop rapid diagnostics, improved treatments and affordable vaccines for emerging infectious diseases. Directed by a senior virologist with assistance from a well-trained staff, the Biocontainment Core has provided opportunities for studying pathogenic microbes under BSL-2 and BSL-3 biocontainment; also, the Core has provided training workshops and assisted in the certification and permitting process for users. During COBRE Phases I and II, the Biocontainment Core focused on the triad of service, research and development, and education and training. These core functions will extend into Phase III to support the career development and research independence of faculty within the UH System and beyond. Further, a high priority during COBRE Phase III is to ensure the sustainability and growth of the Biocontainment Core. Thus, the overarching objective is to facilitate the transition of the Biocontainment Core into a sustainable state-of-the-art core facility capable of supporting high-caliber research on new, emerging and re-emerging infectious diseases. The objective will be achieved by (1) enhancing and streamlining core operations; (2) growing and diversifying the user base, capability, capacity and reach; and (3) strengthening the core infrastructure. It is envisioned that the Biocontainment Core will achieve each of the above-stated specific aims by the end of the Phase III COBRE. Moreover, the strong commitments by high-level institutional officials will ensure that core operations will be sustained during and beyond the Phase III COBRE period.