Dissecting the role of the adipokine leptin in control of the inflammatory response to Helicobacter pylori

剖析脂肪因子瘦素在控制幽门螺杆菌炎症反应中的作用

• 批准号: nhmrc : 566711
• 负责人: A/Pr Odilia Wijburg
• 金额: $ 37.95万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-adipokine-helicobacter-pylori/77150
• 关键词: Dissecting; role; adipokine; leptin; control

Helicobacter pylori is a bacterium that causes chronic gastric inflammation (gastritis), which may lead to cancer. Approximately 20% of Australians are infected. As part of the search for a human vaccine, we are attempting to understand the immune response against this bacterium. This study will investigate a novel observation that adipokines-small proteins produced by fat cells can regulate the actions of immune cells in the stomach and in this way determine whether vaccination works.

幽门螺杆菌是一种引起慢性胃炎（胃炎）的细菌，可能导致癌症。大约20%的澳大利亚人被感染。作为寻找人类疫苗的一部分，我们正在试图了解针对这种细菌的免疫反应。这项研究将调查一个新的观察结果，即脂肪细胞产生的脂肪因子-小蛋白质可以调节胃中免疫细胞的活动，并以这种方式确定疫苗接种是否有效。