Mechanisms of respiratory virus induced pneumococcal infection in the middle ear.

呼吸道病毒诱发中耳肺炎球菌感染的机制。

• 批准号: nhmrc : 1044976
• 负责人: A/Pr Odilia Wijburg
• 金额: $ 43.1万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-respiratory-virus-middle-ear/111706
• 关键词: Mechanisms; respiratory; virus; induced; pneumococcal

Streptococcus pneumoniae (the pneumococcus) is a common bacterium that temporarily lives in the nose of most young children, usually not causing any disease. Predisposing conditions, such as infection with a respiratory virus, may result in development of clinical disease. We will investigate how influenza virus mediates inflammation of the middle ear (otitis media) leading to pneumococcal infection. In particular, modulation of the middle ear innate immune response by viral protein will be studied.

肺炎链球菌（肺炎球菌）是一种常见的细菌，暂时生活在大多数幼儿的鼻子里，通常不会引起任何疾病。易感条件，如呼吸道病毒感染，可能导致临床疾病的发展。我们将研究流感病毒如何介导中耳炎（中耳炎）导致肺炎球菌感染。特别地，将研究病毒蛋白对中耳先天免疫应答的调节。