The role of apoptosis in pathogenesis and immunology of Salmonella infections

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Salmonellae are important human pathogens in developed and developing countries. The most severe salmonella disease, typhoid fever, is becoming more difficult to treat because of increasing antibiotic resistance. In addition, current vaccines only provide short-term protection. The studies in this proposal are designed to answer important questions about immunity against typhoid fever, including how this immunity is provoked, and the direct and indirect causes of pathology in the disease. The focus of this project is the induction of host cell apoptosis, an important virulence mechanism shared by many bacteria and viruses. The research will have direct application to human typhoid and may lead to novel therapies and improved vaccines for typhoid fever.