NERC Environmental Omics Facility (NEOF)

NERC 环境组学设施 (NEOF)

• 批准号: NE/V003860/1
• 负责人: Steve Paterson
• 金额: $ 1274.2万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FV003860%2F1
• 关键词: NERC; Environmental; Omics; Facility; NEOF

New 'omic' technologies have transformed biology by allowing scientists to read genomes (genomics) and to measure the amount of proteins (proteomics) or other chemicals (metabolomics) within living cells and organisms. Tiny amounts of DNA can be collected from the environment (environmental DNA, eDNA) to measure biodiversity and monitor the health of our soils, rivers and seas. This creates a tremendous opportunity to understand the diversity of different individuals and species within the natural environment, their evolution, and the diversity of different characters and forms that allow them to live within their environment. Understanding biodiversity is more pressing than ever, given the rate at which it is being lost from the planet and the central role that it plays in allowing species and ecosystems to respond to, and survive, climate change.Scientists wanting to use omic technologies in their research face significant hurdles: the equipment required costs millions of pounds and few labs can afford it; the expertise to apply these techniques is rare, particularly to species from the natural environment; and there is a lack of the specialist skills present within the environmental science community to design studies using omic technology and to then analyse the resulting data. To overcome these hurdles and equip scientists with the tools and skills they need to address their research questions using omics, we will provide the NERC Environmental Omics Facility (NEOF). NEOF will be a unique capability within the UK that has the expertise and equipment to train scientists in omic methods, help them to understand the potential of the technology and design studies to use it, provide the means to test adventurous ideas, and to support larger-scale NERC research projects. NEOF will be run by a team of scientists who are world-leading experts and are able to cover a broad range of omics methods, with experience of applying these to questions in environmental sciences. We will use this expertise to train early-stage scientists and to upskill scientists at any stage of their career. We will empower the community of NERC scientists to engage with new technologies and approaches and to then use them to address questions using omics that were previously impossible to answer in environmental science. We also have extensive equipment and space that we will use to support omic analysis for NERC scientists. NEOF will be excellent value for NERC. We are able to provide £20m of existing equipment and >£2m of previous refurbishment so that NERC does not need to buy this for us. Our Universities will provide further refurbishment, space and support towards this proposal. Our team has >10 years' experience of delivering a highly effective facility to NERC, with a host of processes in place to ensure that projects are managed quickly and to budget. Because of this, we will be able to hit the ground running and provide this facility immediately to NERC scientists.

新的“组学”技术已经改变了生物学，使科学家能够读取基因组（基因组学），并测量活细胞和生物体内的蛋白质（蛋白质组学）或其他化学物质（代谢组学）的数量。可以从环境中收集微量的DNA（环境DNA，eDNA）来测量生物多样性并监测我们的土壤，河流和海洋的健康状况。这创造了一个巨大的机会来了解自然环境中不同个体和物种的多样性，它们的进化，以及允许它们生活在环境中的不同特征和形式的多样性。考虑到生物多样性正在从地球上消失的速度，以及它在让物种和生态系统应对气候变化并在其中生存下来方面所起的核心作用，了解生物多样性比以往任何时候都更加紧迫。科学家们想要在研究中使用组学技术，面临着巨大的障碍：所需的设备花费数百万英镑，很少有实验室能负担得起;应用这些技术的专门知识很少，特别是对自然环境中的物种;环境科学界缺乏利用组学技术设计研究并分析所得数据的专业技能。为了克服这些障碍，并为科学家提供使用组学解决研究问题所需的工具和技能，我们将提供NERC环境组学设施（NEOF）。NEOF将是英国的一个独特能力，拥有专业知识和设备来培训科学家的组学方法，帮助他们了解技术的潜力和设计研究来使用它，提供测试冒险想法的手段，并支持更大规模的NERC研究项目。NEOF将由一组世界领先的专家组成的科学家团队管理，他们能够涵盖广泛的组学方法，并具有将这些方法应用于环境科学问题的经验。我们将利用这些专业知识来培训早期科学家，并在他们职业生涯的任何阶段提高科学家的技能。我们将授权NERC科学家社区参与新技术和新方法，然后使用它们来解决以前在环境科学中无法回答的问题。我们也有大量的设备和空间，我们将用于支持NERC科学家的组学分析。NEOF将是NERC的绝佳价值。我们能够提供2000万英镑的现有设备和超过200万英镑的以前翻新，这样NERC就不需要为我们购买这个。我们的大学将为这一提议提供进一步的翻新、空间和支持。我们的团队在为NERC提供高效设施方面拥有超过10年的经验，并制定了一系列流程，以确保项目得到快速管理并符合预算。正因为如此，我们将能够立即启动并向NERC科学家提供该设施。

项目成果

Habitat and population structure of the Morelet's crocodile (Crocodylus moreletii) in Calakmul Biosphere Reserve, Campeche, Mexico

墨西哥坎佩切州卡拉克穆尔生物圈保护区莫雷特鳄（Crocodylus moreletii）的栖息地和种群结构

• 发表时间: 2021
• 作者: Bara

Quantifying and characterising organic carbon and microbes in newly developed soils following glacier retreat in northern latitudes

北纬地区冰川退缩后新开发土壤中的有机碳和微生物的量化和表征

• 发表时间: 2023
• 作者: Akhmetkaliyeva Saule

Microbial transformation of arsenic in Bengal floodplain

孟加拉洪泛区砷的微生物转化

• 发表时间: 2021
• 作者: Afroz Hasina

The nature of intraspecific and interspecific genome size variation in taxonomically complex eyebrights.

• DOI: 10.1093/aob/mcab102
• 发表时间: 2021-09-07
• 期刊: Annals of botany
• 影响因子: 4.2
• 作者: Becher H;Powell RF;Brown MR;Metherell C;Pellicer J;Leitch IJ;Twyford AD
• 通讯作者: Twyford AD

Viruses direct carbon cycling in lake sediments under global change.

• DOI: 10.1073/pnas.2202261119
• 发表时间: 2022-10-11
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1